1d8v

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{{Seed}}
 
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[[Image:1d8v.png|left|200px]]
 
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==THE RESTRAINED AND MINIMIZED AVERAGE NMR STRUCTURE OF MAP30.==
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The line below this paragraph, containing "STRUCTURE_1d8v", creates the "Structure Box" on the page.
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<StructureSection load='1d8v' size='340' side='right'caption='[[1d8v]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d8v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D8V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d8v OCA], [https://pdbe.org/1d8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d8v RCSB], [https://www.ebi.ac.uk/pdbsum/1d8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d8v ProSAT]</span></td></tr>
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{{STRUCTURE_1d8v| PDB=1d8v | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIP3_MOMCH RIP3_MOMCH] Irreversibly relaxes supercoiled DNA and catalyzes double-stranded breakage. Acts also as a ribosome inactivating protein.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d8/1d8v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d8v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present the solution structure of MAP30, a plant protein with anti-HIV and anti-tumor activities. Structural analysis and subsequent biochemical assays lead to several novel discoveries. First, MAP30 acts like a DNA glycosylase/apurinic (ap) lyase, an additional activity distinct from its known RNA N-glycosidase activity toward the 28S rRNA. Glycosylase/ap lyase activity explains MAP30's apparent inhibition of the HIV-1 integrase, MAP30's ability to irreversibly relax supercoiled DNA, and may be an alternative cytotoxic pathway that contributes to MAP30's anti-HIV/anti-tumor activities. Second, two distinct, but contiguous, subsites are responsible for MAP30's glycosylase/ap lyase activity. Third, Mn2+ and Zn2+ interact with negatively charged surfaces next to the catalytic sites, facilitating DNA substrate binding instead of directly participating in catalysis.
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===THE RESTRAINED AND MINIMIZED AVERAGE NMR STRUCTURE OF MAP30.===
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Solution structure of anti-HIV-1 and anti-tumor protein MAP30: structural insights into its multiple functions.,Wang YX, Neamati N, Jacob J, Palmer I, Stahl SJ, Kaufman JD, Huang PL, Huang PL, Winslow HE, Pommier Y, Wingfield PT, Lee-Huang S, Bax A, Torchia DA Cell. 1999 Nov 12;99(4):433-42. PMID:10571185<ref>PMID:10571185</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10571185}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1d8v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10571185 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10571185}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1D8V is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D8V OCA].
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==Reference==
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<ref group="xtra">PMID:10571185</ref><references group="xtra"/>
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[[Category: Momordica charantia]]
[[Category: Momordica charantia]]
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[[Category: Jacob, J.]]
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[[Category: Jacob J]]
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[[Category: Neamati, N.]]
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[[Category: Neamati N]]
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[[Category: Palmer, I.]]
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[[Category: Palmer I]]
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[[Category: Stahl, S J.]]
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[[Category: Stahl SJ]]
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[[Category: Wang, Y X.]]
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[[Category: Wang Y-X]]
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[[Category: Single chain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:02:11 2009''
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Current revision

THE RESTRAINED AND MINIMIZED AVERAGE NMR STRUCTURE OF MAP30.

PDB ID 1d8v

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