2b07

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:15, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2b07.png|left|200px]]
 
-
<!--
+
==Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.==
-
The line below this paragraph, containing "STRUCTURE_2b07", creates the "Structure Box" on the page.
+
<StructureSection load='2b07' size='340' side='right'caption='[[2b07]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2b07]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B07 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=598:6-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}-3-(CARBOXYMETHOXY)THIENO[3,2-B][1]BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>598</scene></td></tr>
-
{{STRUCTURE_2b07| PDB=2b07 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b07 OCA], [https://pdbe.org/2b07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b07 RCSB], [https://www.ebi.ac.uk/pdbsum/2b07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b07 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b0/2b07_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b07 ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.===
+
==See Also==
-
 
+
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16303309}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 16303309 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_16303309}}
+
-
 
+
-
==About this Structure==
+
-
2B07 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B07 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:16303309</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein-tyrosine-phosphatase]]
+
[[Category: Large Structures]]
-
[[Category: Binnun, E.]]
+
[[Category: Binnun E]]
-
[[Category: Erbe, D V.]]
+
[[Category: Erbe DV]]
-
[[Category: Follows, B C.]]
+
[[Category: Follows BC]]
-
[[Category: Foreman, K.]]
+
[[Category: Foreman K]]
-
[[Category: Joseph-McCarthy, D.]]
+
[[Category: Joseph-McCarthy D]]
-
[[Category: Kirincich, S J.]]
+
[[Category: Kirincich SJ]]
-
[[Category: Lee, J.]]
+
[[Category: Lee J]]
-
[[Category: Moretto, A F.]]
+
[[Category: Moretto AF]]
-
[[Category: Smith, M J.]]
+
[[Category: Smith MJ]]
-
[[Category: Tam, S K.]]
+
[[Category: Tam SK]]
-
[[Category: Tam, S Y.]]
+
[[Category: Tam SY]]
-
[[Category: Wan, Z K.]]
+
[[Category: Wan ZK]]
-
[[Category: Wilson, D P.]]
+
[[Category: Wilson DP]]
-
[[Category: Xu, W X.]]
+
[[Category: Xu WX]]
-
[[Category: Zhang, Y L.]]
+
[[Category: Zhang YL]]
-
[[Category: Hydrolyase]]
+
-
[[Category: Protein tyrosine phosphatase]]
+
-
[[Category: Tricyclic thiophene]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:08:43 2009''
+

Current revision

Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.

PDB ID 2b07

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b07"
Personal tools