3emi

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{{Seed}}
 
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[[Image:3emi.png|left|200px]]
 
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==Crystal structure of Hia 307-422 non-adhesive domain==
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The line below this paragraph, containing "STRUCTURE_3emi", creates the "Structure Box" on the page.
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<StructureSection load='3emi' size='340' side='right'caption='[[3emi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3emi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EMI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3emi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3emi OCA], [https://pdbe.org/3emi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3emi RCSB], [https://www.ebi.ac.uk/pdbsum/3emi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3emi ProSAT]</span></td></tr>
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{{STRUCTURE_3emi| PDB=3emi | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q48152_HAEIF Q48152_HAEIF]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/em/3emi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3emi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Hia autotransporter of Haemophilus influenzae belongs to the trimeric autotransporter subfamily and mediates bacterial adherence to the respiratory epithelium. In this report, we show that the structure of Hia is characterized by a modular architecture containing repeats of structurally distinct domains. Comparison of the structures of HiaBD1 and HiaBD2 adhesive repeats and a nonadhesive repeat (a novel fold) shed light on the structural determinants of Hia adhesive function. Examination of the structure of an extended version of the Hia translocator domain revealed the structural transition between the C-terminal translocator domain and the N-terminal passenger domain, highlighting a highly intertwined domain that is ubiquitous among trimeric autotransporters. Overall, this study provides important insights into the mechanism of Hia adhesive activity and the overall structure of trimeric autotransporters.
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===Crystal structure of Hia 307-422 non-adhesive domain===
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Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter.,Meng G, St Geme JW 3rd, Waksman G J Mol Biol. 2008 Dec 26;384(4):824-36. Epub 2008 Oct 11. PMID:18948113<ref>PMID:18948113</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3emi" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18948113}}, adds the Publication Abstract to the page
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*[[Adhesin 3D structures|Adhesin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18948113 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18948113}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3EMI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMI OCA].
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==Reference==
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<ref group="xtra">PMID:18948113</ref><references group="xtra"/>
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[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Meng, G.]]
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[[Category: Large Structures]]
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[[Category: Waksman, G.]]
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[[Category: Meng G]]
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[[Category: Cell adhesion]]
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[[Category: Waksman G]]
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[[Category: Haemophilus influenzae]]
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[[Category: Hia adhesin]]
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[[Category: Non-adhesive domain]]
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[[Category: Trimeric autotransporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:13:53 2009''
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Current revision

Crystal structure of Hia 307-422 non-adhesive domain

PDB ID 3emi

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