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2hz6

From Proteopedia

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{{Seed}}
 
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[[Image:2hz6.png|left|200px]]
 
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<!--
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==The crystal structure of human IRE1-alpha luminal domain==
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The line below this paragraph, containing "STRUCTURE_2hz6", creates the "Structure Box" on the page.
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<StructureSection load='2hz6' size='340' side='right'caption='[[2hz6]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HZ6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hz6 OCA], [https://pdbe.org/2hz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2hz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hz6 ProSAT]</span></td></tr>
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{{STRUCTURE_2hz6| PDB=2hz6 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/2hz6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hz6 ConSurf].
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<div style="clear:both"></div>
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===The crystal structure of human IRE1-alpha luminal domain===
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==See Also==
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*[[Ire1|Ire1]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_16973740}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16973740 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16973740}}
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==About this Structure==
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2HZ6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HZ6 OCA].
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==Reference==
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<ref group="xtra">PMID:16973740</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kaufman, R J.]]
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[[Category: Large Structures]]
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[[Category: Xu, Z.]]
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[[Category: Kaufman RJ]]
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[[Category: Zhou, J.]]
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[[Category: Xu Z]]
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[[Category: Triangular beta-sheet cluster]]
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[[Category: Zhou J]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:18:29 2009''
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Current revision

The crystal structure of human IRE1-alpha luminal domain

PDB ID 2hz6

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