1jxo

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{{Seed}}
 
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[[Image:1jxo.png|left|200px]]
 
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==Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95==
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The line below this paragraph, containing "STRUCTURE_1jxo", creates the "Structure Box" on the page.
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<StructureSection load='1jxo' size='340' side='right'caption='[[1jxo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jxo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JXO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxo OCA], [https://pdbe.org/1jxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxo RCSB], [https://www.ebi.ac.uk/pdbsum/1jxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxo ProSAT]</span></td></tr>
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{{STRUCTURE_1jxo| PDB=1jxo | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jxo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jxo ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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PSD-95/SAP90 is a member of the MAGUK superfamily. In excitatory synapses, PSD-95 clusters receptors and ion channels at specific sites in the postsynaptic membrane and organizes downstream signaling and cytoskeletal molecules. We have determined the crystal structures of the apo and GMP-bound forms to 2.3 and 2.0 A resolutions, respectively, of a fragment containing the SH3, HOOK, and guanylate kinase (GK) domains of PSD-95. We observe an intramolecular interaction between the SH3 and GK domains involving the formation of a beta sheet including residues N- and C-terminal to the GK domain. Based on amino acid conservation and mutational data available in the literature, we propose that this intramolecular interaction is a common feature among MAGUK proteins.
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===Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95===
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Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95.,Tavares GA, Panepucci EH, Brunger AT Mol Cell. 2001 Dec;8(6):1313-25. PMID:11779506<ref>PMID:11779506</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1jxo" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11779506}}, adds the Publication Abstract to the page
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*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11779506 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11779506}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1JXO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXO OCA].
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==Reference==
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<ref group="xtra">PMID:11779506</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Brunger, A T.]]
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[[Category: Brunger AT]]
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[[Category: Panepucci, E H.]]
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[[Category: Panepucci EH]]
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[[Category: Tavares, G A.]]
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[[Category: Tavares GA]]
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[[Category: Guanylate kinase domain]]
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[[Category: Maguk]]
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[[Category: Postsynaptic density]]
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[[Category: Sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:22:19 2009''
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Current revision

Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95

PDB ID 1jxo

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