1zse

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{{Seed}}
 
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[[Image:1zse.png|left|200px]]
 
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==RNA stemloop from bacteriophage Qbeta complexed with an N87S mutant MS2 Capsid==
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The line below this paragraph, containing "STRUCTURE_1zse", creates the "Structure Box" on the page.
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<StructureSection load='1zse' size='340' side='right'caption='[[1zse]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zse]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_MS2 Escherichia phage MS2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZSE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zse OCA], [https://pdbe.org/1zse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zse RCSB], [https://www.ebi.ac.uk/pdbsum/1zse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zse ProSAT]</span></td></tr>
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{{STRUCTURE_1zse| PDB=1zse | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_BPMS2 CAPSD_BPMS2] Self-assembles to form the T=3 icosahedral virus shell that protects the viral nucleic acid. Acts as a translational repressor by binding with high specificity to a single stem-loop structure in the genomic RNA that contains the initiation codon of the gene for the viral replicase. Involved in virus assembly through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome.<ref>PMID:16531233</ref> <ref>PMID:18662904</ref> <ref>PMID:26608810</ref> <ref>PMID:8254664</ref> <ref>PMID:9245600</ref> <ref>PMID:9469847</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zse_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zse ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sequence-specific interactions between RNA stem-loops and coat protein (CP) subunits play vital roles in the life cycles of the RNA bacteriophages, e.g., by allowing translational repression of their replicase cistrons and tagging their own RNA genomes for encapsidation. The CPs of bacteriophages Qbeta and MS2 each discriminate in favor of their cognate translational operators, even in the presence of closely related operators from other phages in vivo. Discrete mutations within the MS2 CP have been shown to relax this discrimination in vitro. We have determined the structures of eight complexes between such mutants and both MS2 and Qbeta stem-loops with X-ray crystallography. In conjunction with previously determined in vivo repression data, the structures enable us to propose the molecular basis for the discrimination mechanism.
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===RNA stemloop from bacteriophage Qbeta complexed with an N87S mutant MS2 Capsid===
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Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2.,Horn WT, Tars K, Grahn E, Helgstrand C, Baron AJ, Lago H, Adams CJ, Peabody DS, Phillips SE, Stonehouse NJ, Liljas L, Stockley PG Structure. 2006 Mar;14(3):487-95. PMID:16531233<ref>PMID:16531233</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<!--
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16531233}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1zse" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16531233 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16531233}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia phage MS2]]
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1ZSE is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Enterobacterio_phage_ms2 Enterobacterio phage ms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZSE OCA].
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[[Category: Large Structures]]
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[[Category: Adams CJ]]
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==Reference==
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[[Category: Baron AJ]]
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<ref group="xtra">PMID:16531233</ref><references group="xtra"/>
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[[Category: Grahn E]]
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[[Category: Enterobacterio phage ms2]]
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[[Category: Helgstrand C]]
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[[Category: Adams, C J.]]
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[[Category: Horn WT]]
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[[Category: Baron, A J.]]
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[[Category: Lago H]]
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[[Category: Grahn, E.]]
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[[Category: Liljas L]]
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[[Category: Helgstrand, C.]]
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[[Category: Peabody DS]]
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[[Category: Horn, W T.]]
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[[Category: Phillips SEV]]
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[[Category: Lago, H.]]
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[[Category: Stockley PG]]
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[[Category: Liljas, L.]]
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[[Category: Stonehouse NJ]]
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[[Category: Peabody, D S.]]
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[[Category: Tars K]]
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[[Category: Phillips, S E.V.]]
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[[Category: Stockley, P G.]]
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[[Category: Stonehouse, N J.]]
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[[Category: Tars, K.]]
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[[Category: Capsid]]
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[[Category: Hairpin]]
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[[Category: Levivirus]]
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[[Category: Virus/viral protein/rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:30:53 2009''
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Current revision

RNA stemloop from bacteriophage Qbeta complexed with an N87S mutant MS2 Capsid

PDB ID 1zse

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