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1nkl

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{{Seed}}
 
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[[Image:1nkl.png|left|200px]]
 
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==NK-LYSIN FROM PIG, NMR, 20 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1nkl", creates the "Structure Box" on the page.
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<StructureSection load='1nkl' size='340' side='right'caption='[[1nkl]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NKL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nkl OCA], [https://pdbe.org/1nkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nkl RCSB], [https://www.ebi.ac.uk/pdbsum/1nkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nkl ProSAT]</span></td></tr>
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{{STRUCTURE_1nkl| PDB=1nkl | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NKL_PIG NKL_PIG] May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nk/1nkl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nkl ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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NK-lysin is the first representative of a family of sequence related proteins--saposins, surfactant-associated protein B, pore forming amoeba proteins, and domains of acid sphingomyelinase, acyloxyacylhydrolase and plant aspartic proteinases--for which a structure has been determined.
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===NK-LYSIN FROM PIG, NMR, 20 STRUCTURES===
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Saposin fold revealed by the NMR structure of NK-lysin.,Liepinsh E, Andersson M, Ruysschaert JM, Otting G Nat Struct Biol. 1997 Oct;4(10):793-5. PMID:9334742<ref>PMID:9334742</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1nkl" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_9334742}}, adds the Publication Abstract to the page
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*[[Lysin 3D structures|Lysin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9334742 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9334742}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1NKL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NKL OCA].
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==Reference==
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<ref group="xtra">PMID:9334742</ref><references group="xtra"/>
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Liepinsh, E.]]
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[[Category: Liepinsh E]]
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[[Category: Otting, G.]]
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[[Category: Otting G]]
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[[Category: Antibacterial peptide]]
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[[Category: Saposin fold]]
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[[Category: Tumourolytic peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:05:54 2009''
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Current revision

NK-LYSIN FROM PIG, NMR, 20 STRUCTURES

PDB ID 1nkl

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