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1s3b

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{{Seed}}
 
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[[Image:1s3b.png|left|200px]]
 
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==Crystal structure of MAOB in complex with N-methyl-N-propargyl-1(R)-aminoindan==
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The line below this paragraph, containing "STRUCTURE_1s3b", creates the "Structure Box" on the page.
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<StructureSection load='1s3b' size='340' side='right'caption='[[1s3b]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s3b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S3B FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RMA:N-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YL]-N-METHYL-N-PROP-2-YNYLAMINE'>RMA</scene></td></tr>
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{{STRUCTURE_1s3b| PDB=1s3b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s3b OCA], [https://pdbe.org/1s3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s3b RCSB], [https://www.ebi.ac.uk/pdbsum/1s3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s3b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s3/1s3b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s3b ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of MAOB in complex with N-methyl-N-propargyl-1(R)-aminoindan===
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==See Also==
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*[[Monoamine oxidase|Monoamine oxidase]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15027868}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15027868 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15027868}}
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==About this Structure==
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1S3B is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3B OCA].
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==Reference==
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<ref group="xtra">PMID:15027868</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Binda, C.]]
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[[Category: Large Structures]]
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[[Category: Edmondson, D E.]]
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[[Category: Binda C]]
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[[Category: Herzig, Y.]]
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[[Category: Edmondson DE]]
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[[Category: Hubalek, F.]]
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[[Category: Herzig Y]]
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[[Category: Li, M.]]
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[[Category: Hubalek F]]
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[[Category: Mattevi, A.]]
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[[Category: Li M]]
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[[Category: Sterling, J.]]
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[[Category: Mattevi A]]
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[[Category: Enantioselectivity]]
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[[Category: Sterling J]]
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[[Category: Flavin]]
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[[Category: Human monoamine oxidase]]
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[[Category: Inhibitor binding]]
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[[Category: Rasagiline]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:12:52 2009''
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Current revision

Crystal structure of MAOB in complex with N-methyl-N-propargyl-1(R)-aminoindan

PDB ID 1s3b

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