1on4

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{{Seed}}
 
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[[Image:1on4.png|left|200px]]
 
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==Solution structure of soluble domain of Sco1 from Bacillus Subtilis==
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The line below this paragraph, containing "STRUCTURE_1on4", creates the "Structure Box" on the page.
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<StructureSection load='1on4' size='340' side='right'caption='[[1on4]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1on4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ON4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1on4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1on4 OCA], [https://pdbe.org/1on4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1on4 RCSB], [https://www.ebi.ac.uk/pdbsum/1on4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1on4 ProSAT]</span></td></tr>
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{{STRUCTURE_1on4| PDB=1on4 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCO1_BACSU SCO1_BACSU] Neccessary for insertion of copper into the active site of cytochrome c oxidase. May play a role in copper homeostasis or redox signaling.<ref>PMID:10837475</ref> <ref>PMID:15723536</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1on4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1on4 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sco1, a protein required for the proper assembly of cytochrome c oxidase, has a soluble domain anchored to the cytoplasmic membrane through a single transmembrane segment. The solution structure of the soluble part of apoSco1 from Bacillus subtilis has been solved by NMR and the internal mobility characterized. Its fold places Sco1 in a distinct subgroup of the functionally unrelated thioredoxin proteins. In vitro Sco1 binds copper(I) through a CXXXCP motif and possibly His 135 and copper(II) in two different species, thus suggesting that copper(II) is adventitious more than physiological. The Sco1 structure represents the first structure of this class of proteins, present in a variety of eukaryotic and bacterial organisms, and elucidates a link between copper trafficking proteins and thioredoxins. The availability of the structure has allowed us to model the homologs Sco1 and Sco2 from S. cerevisiae and to discuss the physiological role of the Sco family.
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===Solution structure of soluble domain of Sco1 from Bacillus Subtilis===
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Solution structure of Sco1: a thioredoxin-like protein Involved in cytochrome c oxidase assembly.,Balatri E, Banci L, Bertini I, Cantini F, Ciofi-Baffoni S Structure. 2003 Nov;11(11):1431-43. PMID:14604533<ref>PMID:14604533</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14604533}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1on4" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14604533 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14604533}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1ON4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ON4 OCA].
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==Reference==
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<ref group="xtra">PMID:14604533</ref><references group="xtra"/>
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Balatri, E.]]
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[[Category: Large Structures]]
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[[Category: Banci, L.]]
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[[Category: Balatri E]]
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[[Category: Bertini, I.]]
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[[Category: Banci L]]
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[[Category: Cantini, F.]]
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[[Category: Bertini I]]
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[[Category: Ciofi-Baffoni, S.]]
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[[Category: Cantini F]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: Ciofi-Baffoni S]]
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[[Category: Copper protein]]
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[[Category: Cox assembly protein]]
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[[Category: Nmr structure]]
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[[Category: Sco1 from b. subtili]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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[[Category: Thioredoxin-like fold]]
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[[Category: Ypmq]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:14:57 2009''
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Current revision

Solution structure of soluble domain of Sco1 from Bacillus Subtilis

PDB ID 1on4

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