1osc

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{{Seed}}
 
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[[Image:1osc.png|left|200px]]
 
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==Crystal structure of rat CUTA1 at 2.15 A resolution==
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The line below this paragraph, containing "STRUCTURE_1osc", creates the "Structure Box" on the page.
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<StructureSection load='1osc' size='340' side='right'caption='[[1osc]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1osc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osc OCA], [https://pdbe.org/1osc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osc RCSB], [https://www.ebi.ac.uk/pdbsum/1osc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osc ProSAT]</span></td></tr>
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{{STRUCTURE_1osc| PDB=1osc | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CUTA_RAT CUTA_RAT] May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1osc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CutA1 are a protein family present in bacteria, plants, and animals, including humans. Escherichia coli CutA1 is involved in copper tolerance, whereas mammalian proteins are implicated in the anchoring of acetylcholinesterase in neuronal cell membranes. The x-ray structures of CutA1 from E. coli and rat were determined. Both proteins are trimeric in the crystals and in solution through an inter-subunit beta-sheet formation. Each subunit consists of a ferredoxin-like (beta1alpha1beta2beta3alpha2beta4) fold with an additional strand (beta5), a C-terminal helix (alpha3), and an unusual extended beta-hairpin involving strands beta2 and beta3. The bacterial CutA1 is able to bind copper(II) in vitro through His2Cys coordination in a type II water-accessible site, whereas the rat protein precipitates in the presence of copper(II). The evolutionarily conserved trimeric assembly of CutA1 is reminiscent of the architecture of PII signal transduction proteins. This similarity suggests an intriguing role of CutA1 proteins in signal transduction through allosteric communications between subunits.
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===Crystal structure of rat CUTA1 at 2.15 A resolution===
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The evolutionarily conserved trimeric structure of CutA1 proteins suggests a role in signal transduction.,Arnesano F, Banci L, Benvenuti M, Bertini I, Calderone V, Mangani S, Viezzoli MS J Biol Chem. 2003 Nov 14;278(46):45999-6006. Epub 2003 Aug 29. PMID:12949080<ref>PMID:12949080</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1osc" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12949080}}, adds the Publication Abstract to the page
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*[[CutA1 3D structures|CutA1 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12949080 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12949080}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1OSC is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSC OCA].
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==Reference==
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<ref group="xtra">PMID:12949080</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Arnesano, F.]]
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[[Category: Arnesano F]]
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[[Category: Banci, L.]]
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[[Category: Banci L]]
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[[Category: Benvenuti, M.]]
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[[Category: Benvenuti M]]
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[[Category: Bertini, I.]]
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[[Category: Bertini I]]
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[[Category: Calderone, V.]]
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[[Category: Calderone V]]
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[[Category: Mangani, S.]]
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[[Category: Mangani S]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: Viezzoli MS]]
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[[Category: Viezzoli, M S.]]
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[[Category: Copper resistance]]
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[[Category: Cuta]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:27:31 2009''
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Current revision

Crystal structure of rat CUTA1 at 2.15 A resolution

PDB ID 1osc

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