1sj6

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{{Seed}}
 
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[[Image:1sj6.png|left|200px]]
 
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==NMR Structure and Regulated Expression in APL Cell of Human SH3BGRL3==
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The line below this paragraph, containing "STRUCTURE_1sj6", creates the "Structure Box" on the page.
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<StructureSection load='1sj6' size='340' side='right'caption='[[1sj6]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sj6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJ6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sj6 OCA], [https://pdbe.org/1sj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sj6 RCSB], [https://www.ebi.ac.uk/pdbsum/1sj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sj6 ProSAT]</span></td></tr>
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{{STRUCTURE_1sj6| PDB=1sj6 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SH3L3_HUMAN SH3L3_HUMAN] Could act as a modulator of glutaredoxin biological activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sj6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sj6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SH3 domain binding glutamic acid-rich protein like 3 (SH3BGRL3) is the new member of thioredoxin (TRX) super family, whose posttranslational modified form was identified as tumor necrosis factor alpha (TNF-alpha) inhibitory protein, TIP-B1. In this paper, we determined its solution structure by multi-dimensional nuclear magnetic resonance spectroscopy. The overall structure of human SH3BGRL3 conformed to a TRX-like fold. To understand its function in vivo, the upregulated expression in acute promyelocytic leukemia cell line NB4 at both mRNA and protein level was elucidated. Immunofluorescence and immunohistochemistry staining with monoclonal antibody against SH3BGRL3 demonstrated that it was a cytoplasmic protein in both NB4 cell and human tissues. These results, as a whole, indicate that SH3BGRL3 may function as a regulator in all-trans retinoic acid-induced pathway.
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===NMR Structure and Regulated Expression in APL Cell of Human SH3BGRL3===
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NMR structure and regulated expression in APL cell of human SH3BGRL3.,Xu C, Zheng P, Shen S, Xu Y, Wei L, Gao H, Wang S, Zhu C, Tang Y, Wu J, Zhang Q, Shi Y FEBS Lett. 2005 May 23;579(13):2788-94. Epub 2005 Apr 20. PMID:15907482<ref>PMID:15907482</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15907482}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1sj6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15907482 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15907482}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1SJ6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ6 OCA].
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==Reference==
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<ref group="xtra">PMID:15907482</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Du, Y.]]
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[[Category: Large Structures]]
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[[Category: Shi, Y.]]
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[[Category: Du Y]]
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[[Category: Tang, Y.]]
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[[Category: Shi Y]]
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[[Category: Wu, J.]]
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[[Category: Tang Y]]
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[[Category: Xu, C.]]
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[[Category: Wu J]]
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[[Category: Xu, Y.]]
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[[Category: Xu C]]
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[[Category: Zhang, Q.]]
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[[Category: Xu Y]]
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[[Category: Zheng, P.]]
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[[Category: Zhang Q]]
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[[Category: Nuclear protein]]
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[[Category: Zheng P]]
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[[Category: Thioredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:28:18 2009''
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Current revision

NMR Structure and Regulated Expression in APL Cell of Human SH3BGRL3

PDB ID 1sj6

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