1js3

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{{Seed}}
 
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[[Image:1js3.png|left|200px]]
 
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==Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa==
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The line below this paragraph, containing "STRUCTURE_1js3", creates the "Structure Box" on the page.
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<StructureSection load='1js3' size='340' side='right'caption='[[1js3]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1js3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JS3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=142:CARBIDOPA'>142</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1js3| PDB=1js3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1js3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js3 OCA], [https://pdbe.org/1js3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1js3 RCSB], [https://www.ebi.ac.uk/pdbsum/1js3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1js3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DDC_PIG DDC_PIG] Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1js3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1js3 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa===
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==See Also==
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*[[DOPA decarboxylase|DOPA decarboxylase]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11685243}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11685243 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11685243}}
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==About this Structure==
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1JS3 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JS3 OCA].
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==Reference==
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<ref group="xtra">PMID:11685243</ref><references group="xtra"/>
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[[Category: Aromatic-L-amino-acid decarboxylase]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Borri-Voltattorni, C.]]
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[[Category: Borri-Voltattorni C]]
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[[Category: Burkhard, P.]]
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[[Category: Burkhard P]]
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[[Category: Dominici, P.]]
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[[Category: Dominici P]]
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[[Category: Jansonius, J N.]]
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[[Category: Jansonius JN]]
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[[Category: Malashkevich, V N.]]
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[[Category: Malashkevich VN]]
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[[Category: Carbidopa]]
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[[Category: Dopa decarboxylase]]
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[[Category: Parkinson's disease]]
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[[Category: Vitamin b6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:33:00 2009''
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Current revision

Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa

PDB ID 1js3

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