2bgd

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{{Seed}}
 
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[[Image:2bgd.png|left|200px]]
 
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==Structure-based design of Protein Tyrosine Phosphatase-1B Inhibitors==
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The line below this paragraph, containing "STRUCTURE_2bgd", creates the "Structure Box" on the page.
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<StructureSection load='2bgd' size='340' side='right'caption='[[2bgd]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bgd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BGD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=T1D:5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE+1,1-DIOXIDE'>T1D</scene></td></tr>
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{{STRUCTURE_2bgd| PDB=2bgd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bgd OCA], [https://pdbe.org/2bgd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bgd RCSB], [https://www.ebi.ac.uk/pdbsum/2bgd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bgd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/2bgd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bgd ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
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===STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS===
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Structure-based design of protein tyrosine phosphatase-1B inhibitors.,Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:15863305<ref>PMID:15863305</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2bgd" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15863305}}, adds the Publication Abstract to the page
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15863305 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15863305}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2BGD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BGD OCA].
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==Reference==
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<ref group="xtra">PMID:15863305</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Black, E.]]
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[[Category: Black E]]
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[[Category: Breed, J.]]
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[[Category: Breed J]]
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[[Category: Breeze, A L.]]
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[[Category: Breeze AL]]
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[[Category: Embrey, K.]]
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[[Category: Embrey K]]
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[[Category: Garcia, R.]]
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[[Category: Garcia R]]
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[[Category: Gero, T W.]]
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[[Category: Gero TW]]
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[[Category: Godfrey, L.]]
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[[Category: Godfrey L]]
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[[Category: Kenny, P W.]]
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[[Category: Kenny PW]]
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[[Category: Minshull, C A.]]
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[[Category: Minshull CA]]
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[[Category: Morley, A D.]]
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[[Category: Morley AD]]
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[[Category: Pannifer, A D.]]
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[[Category: Pannifer AD]]
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[[Category: Read, J.]]
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[[Category: Read J]]
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[[Category: Rees, A.]]
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[[Category: Rees A]]
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[[Category: Russell, D J.]]
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[[Category: Russell DJ]]
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[[Category: Toader, D.]]
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[[Category: Toader D]]
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[[Category: Tucker, J.]]
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[[Category: Tucker J]]
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[[Category: 1,2,5-thiadiazolidin-3-one-1]]
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[[Category: 1-dioxide template]]
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[[Category: Hydrolase]]
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[[Category: Protein tyrosine phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:33:43 2009''
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Current revision

Structure-based design of Protein Tyrosine Phosphatase-1B Inhibitors

PDB ID 2bgd

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