2nts

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{{Seed}}
 
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[[Image:2nts.png|left|200px]]
 
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==Crystal Structure of SEK-hVb5.1==
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The line below this paragraph, containing "STRUCTURE_2nts", creates the "Structure Box" on the page.
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<StructureSection load='2nts' size='340' side='right'caption='[[2nts]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2nts]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nts OCA], [https://pdbe.org/2nts PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nts RCSB], [https://www.ebi.ac.uk/pdbsum/2nts PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nts ProSAT]</span></td></tr>
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{{STRUCTURE_2nts| PDB=2nts | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRBC1_HUMAN TRBC1_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2nts_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nts ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Superantigens (SAGs) interact with host immune receptors to induce a massive release of inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can be classified into five distinct evolutionary groups. Group V SAGs are characterized by the alpha3-beta8 loop, a unique approximately 15 amino acid residue extension that is required for optimal T cell activation. Here, we report the X-ray crystal structures of the group V SAG staphylococcal enterotoxin K (SEK) alone and in complex with the TCR hVbeta5.1 domain. SEK adopts a unique TCR binding orientation relative to other SAG-TCR complexes, which results in the alpha3-beta8 loop contacting the apical loop of framework region 4, thereby extending the known TCR recognition site of SAGs. These interactions are absolutely required for TCR binding and T cell activation by SEK, and dictate the TCR Vbeta domain specificity of SEK and other group V SAGs.
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===Crystal Structure of SEK-hVb5.1===
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A novel loop domain in superantigens extends their T cell receptor recognition site.,Gunther S, Varma AK, Moza B, Kasper KJ, Wyatt AW, Zhu P, Rahman AK, Li Y, Mariuzza RA, McCormick JK, Sundberg EJ J Mol Biol. 2007 Aug 3;371(1):210-21. Epub 2007 May 18. PMID:17560605<ref>PMID:17560605</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17560605}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2nts" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17560605 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17560605}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2NTS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTS OCA].
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==Reference==
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<ref group="xtra">PMID:17560605</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Staphylococcus aureus]]
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[[Category: Large Structures]]
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[[Category: Gunther, S.]]
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[[Category: Staphylococcus aureus subsp. aureus COL]]
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[[Category: Moza, B.]]
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[[Category: Gunther S]]
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[[Category: Sundberg, E J.]]
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[[Category: Moza B]]
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[[Category: Varma, A K.]]
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[[Category: Sundberg EJ]]
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[[Category: Superantigen]]
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[[Category: Varma AK]]
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[[Category: T cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:01:28 2009''
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Current revision

Crystal Structure of SEK-hVb5.1

PDB ID 2nts

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OCA

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