2prf

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{{Seed}}
 
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[[Image:2prf.png|left|200px]]
 
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==THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I==
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The line below this paragraph, containing "STRUCTURE_2prf", creates the "Structure Box" on the page.
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<StructureSection load='2prf' size='340' side='right'caption='[[2prf]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2prf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PRF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2prf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prf OCA], [https://pdbe.org/2prf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2prf RCSB], [https://www.ebi.ac.uk/pdbsum/2prf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2prf ProSAT]</span></td></tr>
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{{STRUCTURE_2prf| PDB=2prf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRO1A_ACACA PRO1A_ACACA] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2prf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2prf ConSurf].
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<div style="clear:both"></div>
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===THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I===
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==See Also==
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*[[Profilin 3D Structures|Profilin 3D Structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8397216}}, adds the Publication Abstract to the page
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[[Category: Acanthamoeba sp]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8397216 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Archer SJ]]
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{{ABSTRACT_PUBMED_8397216}}
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[[Category: Lattman EE]]
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[[Category: Pollard TD]]
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==About this Structure==
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[[Category: Torchia DA]]
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2PRF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_sp. Acanthamoeba sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRF OCA].
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[[Category: Vinson VK]]
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==Reference==
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<ref group="xtra">PMID:8397216</ref><references group="xtra"/>
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[[Category: Acanthamoeba sp.]]
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[[Category: Archer, S J.]]
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[[Category: Lattman, E E.]]
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[[Category: Pollard, T D.]]
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[[Category: Torchia, D A.]]
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[[Category: Vinson, V K.]]
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[[Category: Actin-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:08:51 2009''
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Current revision

THREE DIMENSIONAL SOLUTION STRUCTURE OF ACANTHAMOEBA PROFILIN I

PDB ID 2prf

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