1h0x

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{{Seed}}
 
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[[Image:1h0x.png|left|200px]]
 
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==Structure of Alba: an archaeal chromatin protein modulated by acetylation==
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The line below this paragraph, containing "STRUCTURE_1h0x", creates the "Structure Box" on the page.
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<StructureSection load='1h0x' size='340' side='right'caption='[[1h0x]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h0x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0x OCA], [https://pdbe.org/1h0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0x RCSB], [https://www.ebi.ac.uk/pdbsum/1h0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0x ProSAT]</span></td></tr>
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{{STRUCTURE_1h0x| PDB=1h0x | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALBA1_SACS2 ALBA1_SACS2] Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. May be involved in DNA compaction. May bind rRNA and mRNA, playing a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h0x ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Eukaryotic DNA is packaged into nucleosomes that regulate the accessibility of the genome to replication, transcription and repair factors. Chromatin accessibility is controlled by histone modifications including acetylation and methylation. Archaea possess eukary otic-like machineries for DNA replication, transcription and information processing. The conserved archaeal DNA binding protein Alba (formerly Sso10b) interacts with the silencing protein Sir2, which regulates Alba's DNA binding affinity by deacetylation of a lysine residue. We present the crystal structure of Alba from Sulfolobus solfataricus at 2.6 A resolution (PDB code 1h0x). The fold is reminiscent of the N-terminal DNA binding domain of DNase I and the C-terminal domain of initiation factor IF3. The Alba dimer has two extended beta-hairpins flanking a central body containing the acetylated lysine, Lys16, suggesting three main points of contact with the DNA. Fluorescence, calorimetry and electrophoresis data suggest a final binding stoichiometry of approximately 5 bp DNA per Alba dimer. We present a model for the Alba-DNA interaction consistent with the available structural, biophysical and electron microscopy data.
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===STRUCTURE OF ALBA: AN ARCHAEAL CHROMATIN PROTEIN MODULATED BY ACETYLATION===
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Structure of Alba: an archaeal chromatin protein modulated by acetylation.,Wardleworth BN, Russell RJ, Bell SD, Taylor GL, White MF EMBO J. 2002 Sep 2;21(17):4654-62. PMID:12198167<ref>PMID:12198167</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12198167}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1h0x" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12198167 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12198167}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1H0X is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0X OCA].
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[[Category: Saccharolobus solfataricus]]
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[[Category: Bell SD]]
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==Reference==
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[[Category: Russell RJM]]
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<ref group="xtra">PMID:12198167</ref><references group="xtra"/>
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[[Category: Taylor GL]]
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[[Category: Sulfolobus solfataricus]]
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[[Category: Wardleworth BN]]
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[[Category: Bell, S D.]]
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[[Category: White MF]]
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[[Category: Russell, R J.M.]]
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[[Category: Taylor, G L.]]
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[[Category: Wardleworth, B N.]]
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[[Category: White, M F.]]
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[[Category: Acetylation]]
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[[Category: Alba]]
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[[Category: Archaea]]
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[[Category: Chromatin]]
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[[Category: Dna binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:09:46 2009''
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Current revision

Structure of Alba: an archaeal chromatin protein modulated by acetylation

PDB ID 1h0x

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