2p24

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{{Seed}}
 
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[[Image:2p24.png|left|200px]]
 
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==I-Au/MBP125-135==
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The line below this paragraph, containing "STRUCTURE_2p24", creates the "Structure Box" on the page.
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<StructureSection load='2p24' size='340' side='right'caption='[[2p24]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2p24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P24 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p24 OCA], [https://pdbe.org/2p24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p24 RCSB], [https://www.ebi.ac.uk/pdbsum/2p24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p24 ProSAT]</span></td></tr>
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{{STRUCTURE_2p24| PDB=2p24 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HA2U_MOUSE HA2U_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p2/2p24_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p24 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report crystal structures of a negatively selected T cell receptor (TCR) that recognizes two I-A(u)-restricted myelin basic protein peptides and one of its peptide/major histocompatibility complex (pMHC) ligands. Unusual complementarity-determining region (CDR) structural features revealed by our analyses identify a previously unrecognized mechanism by which the highly variable CDR3 regions define ligand specificity. In addition to the pMHC contact residues contributed by CDR3, the CDR3 residues buried deep within the V alpha/V beta interface exert indirect effects on recognition by influencing the V alpha/V beta interdomain angle. This phenomenon represents an additional mechanism for increasing the potential diversity of the TCR repertoire. Both the direct and indirect effects exerted by CDR residues can impact global TCR/MHC docking. Analysis of the available TCR structures in light of these results highlights the significance of the V alpha/V beta interdomain angle in determining specificity and indicates that TCR/pMHC interface features do not distinguish autoimmune from non-autoimmune class II-restricted TCRs.
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===I-Au/MBP125-135===
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A new twist in TCR diversity revealed by a forbidden alphabeta TCR.,McBeth C, Seamons A, Pizarro JC, Fleishman SJ, Baker D, Kortemme T, Goverman JM, Strong RK J Mol Biol. 2008 Feb 1;375(5):1306-19. Epub 2007 Nov 17. PMID:18155234<ref>PMID:18155234</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2p24" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18155234}}, adds the Publication Abstract to the page
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*[[MHC 3D structures|MHC 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18155234 is the PubMed ID number.
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*[[MHC II 3D structures|MHC II 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_18155234}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2P24 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P24 OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:18155234</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: McBeth, C.]]
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[[Category: McBeth C]]
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[[Category: Strong, R K.]]
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[[Category: Strong RK]]
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[[Category: I-au]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin fold]]
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[[Category: Mbp]]
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[[Category: Mhc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:13:46 2009''
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Current revision

I-Au/MBP125-135

PDB ID 2p24

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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