3c60

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{{Seed}}
 
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[[Image:3c60.png|left|200px]]
 
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==Crystal structure of mouse MHC class II I-Ab/3K peptide complexed with mouse TCR YAe62==
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The line below this paragraph, containing "STRUCTURE_3c60", creates the "Structure Box" on the page.
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<StructureSection load='3c60' size='340' side='right'caption='[[3c60]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c60]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C60 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c60 OCA], [https://pdbe.org/3c60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c60 RCSB], [https://www.ebi.ac.uk/pdbsum/3c60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c60 ProSAT]</span></td></tr>
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{{STRUCTURE_3c60| PDB=3c60 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HB2A_MOUSE HB2A_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/3c60_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c60 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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To test whether highly crossreactive alphabeta T cell receptors (TCRs) produced during limited negative selection best illustrate evolutionarily conserved interactions between TCR and major histocompatibility complex (MHC) molecules, we solved the structures of three TCRs bound to the same MHC II peptide (IAb-3K). The TCRs had similar affinities for IAb-3K but varied from noncrossreactive to extremely crossreactive with other peptides and MHCs. Crossreactivity correlated with a shrinking, increasingly hydrophobic TCR-ligand interface, involving fewer TCR amino acids. A few CDR1 and CDR2 amino acids dominated the most crossreactive TCR interface with MHC, including Vbeta8 48Y and 54E and Valpha4 29Y, arranged to impose the familiar diagonal orientation of TCR on MHC. These interactions contribute to MHC binding by other TCRs using related V regions, but not usually so dominantly. These data show that crossreactive TCRs can spotlight the evolutionarily conserved features of TCR-MHC interactions and that these interactions impose the diagonal docking of TCRs on MHC.
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===Crystal structure of mouse MHC class II I-Ab/3K peptide complexed with mouse TCR YAe62===
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Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules.,Dai S, Huseby ES, Rubtsova K, Scott-Browne J, Crawford F, Macdonald WA, Marrack P, Kappler JW Immunity. 2008 Mar;28(3):324-34. Epub 2008 Feb 28. PMID:18308592<ref>PMID:18308592</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3c60" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18308592}}, adds the Publication Abstract to the page
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*[[MHC 3D structures|MHC 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18308592 is the PubMed ID number.
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*[[MHC II 3D structures|MHC II 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_18308592}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3C60 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C60 OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:18308592</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Dai, S.]]
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[[Category: Dai S]]
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[[Category: Glycoprotein]]
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[[Category: Immune response]]
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[[Category: Membrane]]
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[[Category: Mhc ii]]
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[[Category: Sugar binding protein/immune system complex]]
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[[Category: Tcr-pmhc complex]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:19:46 2009''
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Current revision

Crystal structure of mouse MHC class II I-Ab/3K peptide complexed with mouse TCR YAe62

PDB ID 3c60

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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