1zhn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:45, 30 October 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1zhn.png|left|200px]]
 
-
<!--
+
==Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine==
-
The line below this paragraph, containing "STRUCTURE_1zhn", creates the "Structure Box" on the page.
+
<StructureSection load='1zhn' size='340' side='right'caption='[[1zhn]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1zhn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZHN FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PC6:7-[(DODECANOYLOXY)METHYL]-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-3,5,8-TRIOXA-4-PHOSPHADOTRIACONTAN-1-AMINIUM+4-OXIDE'>PC6</scene></td></tr>
-
{{STRUCTURE_1zhn| PDB=1zhn | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhn OCA], [https://pdbe.org/1zhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zhn RCSB], [https://www.ebi.ac.uk/pdbsum/1zhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zhn ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zh/1zhn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zhn ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
NKT cells are immunoregulatory lymphocytes whose activation is triggered by the recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we present the crystal structure to 2.8 A of mouse CD1d bound to phosphatidylcholine. The interactions between the ligand acyl chains and the CD1d molecule define the structural and chemical requirements for the binding of lipid Ags to CD1d. The orientation of the polar headgroup toward the C terminus of the alpha1 helix provides a rationale for the structural basis for the observed Valpha chain bias in invariant NKT cells. The contribution of the ligand to the protein surface suggests a likely mode of recognition of lipid Ags by the NKT cell TCR.
-
===Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine===
+
Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation.,Giabbai B, Sidobre S, Crispin MD, Sanchez-Ruiz Y, Bachi A, Kronenberg M, Wilson IA, Degano M J Immunol. 2005 Jul 15;175(2):977-84. PMID:16002697<ref>PMID:16002697</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1zhn" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16002697}}, adds the Publication Abstract to the page
+
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16002697 is the PubMed ID number.
+
*[[CD1|CD1]]
-
-->
+
== References ==
-
{{ABSTRACT_PUBMED_16002697}}
+
<references/>
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
1ZHN is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHN OCA].
+
[[Category: Large Structures]]
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:16002697</ref><references group="xtra"/>
+
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Bachi, A.]]
+
[[Category: Bachi A]]
-
[[Category: Crispin, M M.D.]]
+
[[Category: Crispin MMD]]
-
[[Category: Degano, M.]]
+
[[Category: Degano M]]
-
[[Category: Giabbai, B.]]
+
[[Category: Giabbai B]]
-
[[Category: Kronenberg, M.]]
+
[[Category: Kronenberg M]]
-
[[Category: Ruiz, Y Sanchez.]]
+
[[Category: Sanchez Ruiz Y]]
-
[[Category: Sidobre, S.]]
+
[[Category: Sidobre S]]
-
[[Category: Wilson, I A.]]
+
[[Category: Wilson IA]]
-
[[Category: Antigen binding domain]]
+
-
[[Category: Ig fold]]
+
-
[[Category: Mhc fold]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:24:31 2009''
+

Current revision

Crystal Structure of mouse CD1d bound to the self ligand phosphatidylcholine

PDB ID 1zhn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zhn"
Personal tools