1lay

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{{Seed}}
 
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[[Image:1lay.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF CYTOMEGALOVIRUS PROTEASE==
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The line below this paragraph, containing "STRUCTURE_1lay", creates the "Structure Box" on the page.
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<StructureSection load='1lay' size='340' side='right'caption='[[1lay]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lay]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cytomegalovirus Cytomegalovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LAY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lay OCA], [https://pdbe.org/1lay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lay RCSB], [https://www.ebi.ac.uk/pdbsum/1lay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lay ProSAT]</span></td></tr>
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{{STRUCTURE_1lay| PDB=1lay | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCAF_HCMVA SCAF_HCMVA] Capsid scaffolding protein acts as a scaffold protein by binding major capsid protein UL86 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein UL86. Cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assemblin is a protease essential for virion assembly in the nucleus. Catalyzes the cleavage of the assembly protein after complete capsid formation. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assembly protein plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein UL86. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/la/1lay_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lay ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF CYTOMEGALOVIRUS PROTEASE===
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8805707}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8805707 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8805707}}
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==About this Structure==
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1LAY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Cytomegalovirus Cytomegalovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LAY OCA].
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==Reference==
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<ref group="xtra">PMID:8805707</ref><references group="xtra"/>
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[[Category: Cytomegalovirus]]
[[Category: Cytomegalovirus]]
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[[Category: Abdel-Meguid, S S.]]
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[[Category: Large Structures]]
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[[Category: Culp, J S.]]
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[[Category: Abdel-Meguid SS]]
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[[Category: Dilella, A G.]]
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[[Category: Culp JS]]
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[[Category: Hellmig, B.]]
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[[Category: Dilella AG]]
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[[Category: Hoog, S S.]]
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[[Category: Hellmig B]]
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[[Category: Jason, C A.]]
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[[Category: Hoog SS]]
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[[Category: Qiu, X.]]
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[[Category: Jason CA]]
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[[Category: Smith, W W.]]
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[[Category: Qiu X]]
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[[Category: Cytomegalovirus]]
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[[Category: Smith WW]]
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[[Category: Serine protease]]
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[[Category: Viral protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:40:39 2009''
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Current revision

CRYSTAL STRUCTURE OF CYTOMEGALOVIRUS PROTEASE

PDB ID 1lay

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