1g4b
From Proteopedia
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- | {{Seed}} | ||
- | [[Image:1g4b.png|left|200px]] | ||
- | + | ==CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM== | |
- | + | <StructureSection load='1g4b' size='340' side='right'caption='[[1g4b]], [[Resolution|resolution]] 7.00Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[1g4b]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G4B FirstGlance]. <br> | |
- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 7Å</td></tr> | |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g4b OCA], [https://pdbe.org/1g4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g4b RCSB], [https://www.ebi.ac.uk/pdbsum/1g4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g4b ProSAT]</span></td></tr> | |
- | + | </table> | |
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/HSLU_ECOLI HSLU_ECOLI] ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.<ref>PMID:8662828</ref> <ref>PMID:8650174</ref> <ref>PMID:9288941</ref> <ref>PMID:9393683</ref> <ref>PMID:10452560</ref> <ref>PMID:10419524</ref> <ref>PMID:15696175</ref> | ||
+ | == Evolutionary Conservation == | ||
+ | [[Image:Consurf_key_small.gif|200px|right]] | ||
+ | Check<jmol> | ||
+ | <jmolCheckbox> | ||
+ | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/1g4b_consurf.spt"</scriptWhenChecked> | ||
+ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
+ | <text>to colour the structure by Evolutionary Conservation</text> | ||
+ | </jmolCheckbox> | ||
+ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g4b ConSurf]. | ||
+ | <div style="clear:both"></div> | ||
- | == | + | ==See Also== |
- | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | |
- | + | == References == | |
- | + | <references/> | |
- | + | __TOC__ | |
- | + | </StructureSection> | |
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- | == | + | |
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
- | [[Category: Chung | + | [[Category: Large Structures]] |
- | [[Category: Eom | + | [[Category: Chung CH]] |
- | [[Category: Franklin | + | [[Category: Eom SH]] |
- | [[Category: Im | + | [[Category: Franklin MC]] |
- | [[Category: Kamtekar | + | [[Category: Im YJ]] |
- | [[Category: Lee | + | [[Category: Kamtekar S]] |
- | [[Category: Rho | + | [[Category: Lee CS]] |
- | [[Category: Seong | + | [[Category: Rho SH]] |
- | [[Category: Song | + | [[Category: Seong IS]] |
- | [[Category: Wang | + | [[Category: Song JJ]] |
- | + | [[Category: Wang J]] | |
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Current revision
CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM
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Categories: Escherichia coli | Large Structures | Chung CH | Eom SH | Franklin MC | Im YJ | Kamtekar S | Lee CS | Rho SH | Seong IS | Song JJ | Wang J