2r5a

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{{Seed}}
 
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[[Image:2r5a.png|left|200px]]
 
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==Crystal Structure of the two MBT repeats from Sex-Comb on Midleg (SCM) in complex with methyl lysine==
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The line below this paragraph, containing "STRUCTURE_2r5a", creates the "Structure Box" on the page.
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<StructureSection load='2r5a' size='340' side='right'caption='[[2r5a]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r5a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
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{{STRUCTURE_2r5a| PDB=2r5a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5a OCA], [https://pdbe.org/2r5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5a RCSB], [https://www.ebi.ac.uk/pdbsum/2r5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCM_DROME SCM_DROME] Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.<ref>PMID:15280237</ref> [UniProtKB:Q9W3C1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5a ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the two MBT repeats from Sex-Comb on Midleg (SCM) in complex with methyl lysine===
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==See Also==
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*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17932512 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17932512}}
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==About this Structure==
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2R5A is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5A OCA].
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==Reference==
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<ref group="xtra">PMID:17932512</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Grimm, C.]]
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[[Category: Large Structures]]
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[[Category: Mueller, C W.]]
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[[Category: Grimm C]]
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[[Category: Steuerwald, U.]]
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[[Category: Mueller CW]]
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[[Category: Chromatin regulator]]
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[[Category: Steuerwald U]]
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[[Category: Developmental protein]]
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[[Category: Mbt]]
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[[Category: Mbt repeat]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Polycomb]]
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[[Category: Repressor]]
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[[Category: Scm]]
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[[Category: Sex comb on midleg]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:46:14 2009''
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Current revision

Crystal Structure of the two MBT repeats from Sex-Comb on Midleg (SCM) in complex with methyl lysine

PDB ID 2r5a

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