This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2z6w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:23, 1 November 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2z6w.png|left|200px]]
 
-
<!--
+
==Crystal structure of human cyclophilin D in complex with cyclosporin A==
-
The line below this paragraph, containing "STRUCTURE_2z6w", creates the "Structure Box" on the page.
+
<StructureSection load='2z6w' size='340' side='right'caption='[[2z6w]], [[Resolution|resolution]] 0.96&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2z6w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z6W FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.96&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
-
{{STRUCTURE_2z6w| PDB=2z6w | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6w OCA], [https://pdbe.org/2z6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z6w RCSB], [https://www.ebi.ac.uk/pdbsum/2z6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z6w ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/2z6w_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z6w ConSurf].
 +
<div style="clear:both"></div>
-
===Crystal structure of human cyclophilin D in complex with cyclosporin A===
+
==See Also==
-
 
+
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2Z6W is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6W OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
-
<ref group="xtra">PMID:18076075</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Peptidylprolyl isomerase]]
+
[[Category: Large Structures]]
[[Category: Tolypocladium inflatum]]
[[Category: Tolypocladium inflatum]]
-
[[Category: Fujihashi, M.]]
+
[[Category: Fujihashi M]]
-
[[Category: Kajitani, K.]]
+
[[Category: Kajitani K]]
-
[[Category: Kobayashi, Y.]]
+
[[Category: Kobayashi Y]]
-
[[Category: Miki, K.]]
+
[[Category: Miki K]]
-
[[Category: Shimizu, S.]]
+
[[Category: Shimizu S]]
-
[[Category: Tsujimoto, Y.]]
+
[[Category: Tsujimoto Y]]
-
[[Category: Cyclosporin]]
+
-
[[Category: Isomerase]]
+
-
[[Category: Mitochondrion]]
+
-
[[Category: Protein-ligand complex]]
+
-
[[Category: Rotamase]]
+
-
[[Category: Transit peptide]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:06:55 2009''
+

Current revision

Crystal structure of human cyclophilin D in complex with cyclosporin A

PDB ID 2z6w

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2z6w"
Personal tools