2tgf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:58, 23 October 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2tgf.png|left|200px]]
 
-
<!--
+
==THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA==
-
The line below this paragraph, containing "STRUCTURE_2tgf", creates the "Structure Box" on the page.
+
<StructureSection load='2tgf' size='340' side='right'caption='[[2tgf]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2tgf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2TGF FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2tgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2tgf OCA], [https://pdbe.org/2tgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2tgf RCSB], [https://www.ebi.ac.uk/pdbsum/2tgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2tgf ProSAT]</span></td></tr>
-
{{STRUCTURE_2tgf| PDB=2tgf | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TGFA_HUMAN TGFA_HUMAN] TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/2tgf_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2tgf ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The solution structure of transforming growth factor alpha has been determined by a combination of high-resolution 1H-nuclear magnetic resonance and distance geometry and restrained molecular dynamics. The 382 restraints derived from the NMR experiments were used to calculate many distance geometry structures, which were then refined by restrained molecular mechanics. Five of these structures were further refined using a variety of methods. Comparison of independently measured parameters, such as calculated hydrogen bonding patterns and experimental amide exchange rates, have been used to evaluate the accuracy of the structures. Also, possible mechanisms to explain the pH-dependent conformational interconversion observed are suggested. Finally comparisons between this work and others on this topic have been made.
-
===THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA===
+
The solution structure of human transforming growth factor alpha.,Harvey TS, Wilkinson AJ, Tappin MJ, Cooke RM, Campbell ID Eur J Biochem. 1991 Jun 15;198(3):555-62. PMID:2050136<ref>PMID:2050136</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_2050136}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2tgf" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 2050136 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_2050136}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2TGF is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2TGF OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:2050136</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Campbell, I D.]]
+
[[Category: Large Structures]]
-
[[Category: Cooke, R M.]]
+
[[Category: Campbell ID]]
-
[[Category: Harvey, T S.]]
+
[[Category: Cooke RM]]
-
[[Category: Tappin, M J.]]
+
[[Category: Harvey TS]]
-
[[Category: Wilkinson, A J.]]
+
[[Category: Tappin MJ]]
-
[[Category: Growth factor]]
+
[[Category: Wilkinson AJ]]
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:26:10 2009''
+

Current revision

THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA

PDB ID 2tgf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2tgf"
Personal tools