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2vsm

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{{Seed}}
 
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[[Image:2vsm.png|left|200px]]
 
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==Nipah virus attachment glycoprotein in complex with human cell surface receptor ephrinB2==
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The line below this paragraph, containing "STRUCTURE_2vsm", creates the "Structure Box" on the page.
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<StructureSection load='2vsm' size='340' side='right'caption='[[2vsm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vsm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Nipah_henipavirus Nipah henipavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VSM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_2vsm| PDB=2vsm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsm OCA], [https://pdbe.org/2vsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vsm RCSB], [https://www.ebi.ac.uk/pdbsum/2vsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLYCP_NIPAV GLYCP_NIPAV] Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:17470910</ref> <ref>PMID:15961384</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vsm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vsm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nipah and Hendra viruses are emergent paramyxoviruses, causing disease characterized by rapid onset and high mortality rates, resulting in their classification as Biosafety Level 4 pathogens. Their attachment glycoproteins are essential for the recognition of the cell-surface receptors ephrin-B2 (EFNB2) and ephrin-B3 (EFNB3). Here we report crystal structures of both Nipah and Hendra attachment glycoproteins in complex with human EFNB2. In contrast to previously solved paramyxovirus attachment complexes, which are mediated by sialic acid interactions, the Nipah and Hendra complexes are maintained by an extensive protein-protein interface, including a crucial phenylalanine side chain on EFNB2 that fits snugly into a hydrophobic pocket on the viral protein. By analogy with the development of antivirals against sialic acid binding viruses, these results provide a structural template to target antiviral inhibition of protein-protein interactions.
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===NIPAH VIRUS ATTACHMENT GLYCOPROTEIN IN COMPLEX WITH HUMAN CELL SURFACE RECEPTOR EPHRINB2===
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Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2.,Bowden TA, Aricescu AR, Gilbert RJ, Grimes JM, Jones EY, Stuart DI Nat Struct Mol Biol. 2008 Jun;15(6):567-72. Epub 2008 May 18. PMID:18488039<ref>PMID:18488039</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2vsm" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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2VSM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Nipah_virus Nipah virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSM OCA].
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*[[Ephrin|Ephrin]]
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[[Category: Exo-alpha-sialidase]]
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*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Nipah virus]]
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[[Category: Large Structures]]
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[[Category: Aricescu, A R.]]
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[[Category: Nipah henipavirus]]
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[[Category: Bowden, T A.]]
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[[Category: Aricescu AR]]
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[[Category: Gilbert, R J.]]
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[[Category: Bowden TA]]
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[[Category: Grimes, J M.]]
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[[Category: Gilbert RJ]]
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[[Category: Jones, E Y.]]
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[[Category: Grimes JM]]
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[[Category: Stuart, D I.]]
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[[Category: Jones EY]]
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[[Category: B2]]
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[[Category: Stuart DI]]
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[[Category: Cell surface receptor]]
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[[Category: Complex]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Efn]]
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[[Category: Envelope protein]]
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[[Category: Eph]]
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[[Category: Ephrin]]
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[[Category: Glycoprotein]]
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[[Category: Hemagglutinin]]
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[[Category: Hendra]]
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[[Category: Henipavirus]]
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[[Category: Hev]]
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[[Category: Hev-g]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Neurogenesis]]
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[[Category: Nipah]]
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[[Category: Niv]]
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[[Category: Niv-g]]
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[[Category: Paramyxovirus]]
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[[Category: Phosphoprotein]]
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[[Category: Signal-anchor]]
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[[Category: Transmembrane]]
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[[Category: Viral attachment]]
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[[Category: Virion]]
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[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:26:24 2009''
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Current revision

Nipah virus attachment glycoprotein in complex with human cell surface receptor ephrinB2

PDB ID 2vsm

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