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3e0d

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{{Seed}}
 
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[[Image:3e0d.png|left|200px]]
 
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==Insights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunit==
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The line below this paragraph, containing "STRUCTURE_3e0d", creates the "Structure Box" on the page.
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<StructureSection load='3e0d' size='340' side='right'caption='[[3e0d]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3e0d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E0D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene></td></tr>
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{{STRUCTURE_3e0d| PDB=3e0d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e0d OCA], [https://pdbe.org/3e0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e0d RCSB], [https://www.ebi.ac.uk/pdbsum/3e0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e0d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPO3A_THEAQ DPO3A_THEAQ] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/3e0d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e0d ConSurf].
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<div style="clear:both"></div>
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===Insights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunit===
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_18691598}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18691598 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18691598}}
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==About this Structure==
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3E0D is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E0D OCA].
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==Reference==
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<ref group="xtra">PMID:18691598</ref><references group="xtra"/>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Thermus aquaticus]]
[[Category: Thermus aquaticus]]
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[[Category: Bailey, S.]]
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[[Category: Bailey S]]
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[[Category: Steitz, T A.]]
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[[Category: Steitz TA]]
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[[Category: Wing, R A.]]
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[[Category: Wing RA]]
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[[Category: Beta barrel]]
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[[Category: Cytoplasm]]
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[[Category: Dna replication]]
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[[Category: Dna-directed dna polymerase]]
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[[Category: Nucleotidyl transferase]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Ob fold]]
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[[Category: Polymerase]]
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[[Category: Transferase]]
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[[Category: Transferase/dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:39:54 2009''
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Current revision

Insights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunit

PDB ID 3e0d

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