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1z8a

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{{Seed}}
 
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[[Image:1z8a.png|left|200px]]
 
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==Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor==
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The line below this paragraph, containing "STRUCTURE_1z8a", creates the "Structure Box" on the page.
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<StructureSection load='1z8a' size='340' side='right'caption='[[1z8a]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=62P:6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE'>62P</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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{{STRUCTURE_1z8a| PDB=1z8a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8a OCA], [https://pdbe.org/1z8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8a RCSB], [https://www.ebi.ac.uk/pdbsum/1z8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z8a ConSurf].
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<div style="clear:both"></div>
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===Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor===
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==See Also==
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16337231}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16337231 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16337231}}
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==About this Structure==
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1Z8A is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8A OCA].
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==Reference==
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<ref group="xtra">PMID:16337231</ref><references group="xtra"/>
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Heine, A.]]
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[[Category: Large Structures]]
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[[Category: Klebe, G.]]
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[[Category: Heine A]]
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[[Category: Podjarny, A.]]
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[[Category: Klebe G]]
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[[Category: Steuber, H.]]
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[[Category: Podjarny A]]
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[[Category: Zentgraf, M.]]
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[[Category: Steuber H]]
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[[Category: Double conformation]]
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[[Category: Zentgraf M]]
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[[Category: Protein-ligand complex]]
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[[Category: Tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:02:53 2009''
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Current revision

Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor

PDB ID 1z8a

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