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3buk

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{{Seed}}
 
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[[Image:3buk.png|left|200px]]
 
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==Crystal Structure of the Neurotrophin-3 and p75NTR Symmetrical Complex==
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The line below this paragraph, containing "STRUCTURE_3buk", creates the "Structure Box" on the page.
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<StructureSection load='3buk' size='340' side='right'caption='[[3buk]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3buk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BUK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3buk| PDB=3buk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3buk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3buk OCA], [https://pdbe.org/3buk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3buk RCSB], [https://www.ebi.ac.uk/pdbsum/3buk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3buk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NTF3_HUMAN NTF3_HUMAN] Seems to promote the survival of visceral and proprioceptive sensory neurons.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/3buk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3buk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT. The question of whether NTs stimulate p75(NTR) by inducing receptor homodimerization is still under debate. Here we report the 2.6-A resolution crystal structure of neurotrophin-3 (NT-3) complexed to the ectodomain of glycosylated p75(NTR). In contrast to the previously reported asymmetric complex structure, which contains a dimer of nerve growth factor (NGF) bound to a single ectodomain of deglycosylated p75(NTR) (ref. 3), we show that NT-3 forms a central homodimer around which two glycosylated p75(NTR) molecules bind symmetrically. Symmetrical binding occurs along the NT-3 interfaces, resulting in a 2:2 ligand-receptor cluster. A comparison of the symmetrical and asymmetric structures reveals significant differences in ligand-receptor interactions and p75(NTR) conformations. Biochemical experiments indicate that both NT-3 and NGF bind to p75(NTR) with 2:2 stoichiometry in solution, whereas the 2:1 complexes are the result of artificial deglycosylation. We therefore propose that the symmetrical 2:2 complex reflects a native state of p75(NTR) activation at the cell surface. These results provide a model for NTs-p75(NTR) recognition and signal generation, as well as insights into coordination between p75(NTR) and Trks.
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===Crystal Structure of the Neurotrophin-3 and p75NTR Symmetrical Complex===
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Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex.,Gong Y, Cao P, Yu HJ, Jiang T Nature. 2008 Aug 7;454(7205):789-93. Epub 2008 Jul 2. PMID:18596692<ref>PMID:18596692</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3buk" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_18596692}}, adds the Publication Abstract to the page
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*[[Neurotrophin|Neurotrophin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 18596692 is the PubMed ID number.
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*[[Neutrotrophin|Neutrotrophin]]
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*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
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{{ABSTRACT_PUBMED_18596692}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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3BUK is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BUK OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:18596692</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Cao, P.]]
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[[Category: Cao P]]
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[[Category: Gong, Y.]]
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[[Category: Gong Y]]
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[[Category: Jiang, T.]]
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[[Category: Jiang T]]
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[[Category: Yu, H J.]]
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[[Category: Yu HJ]]
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[[Category: Apoptosis]]
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[[Category: Beta-sheet]]
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[[Category: Cleavage on pair of basic residue]]
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[[Category: Developmental protein]]
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[[Category: Differentiation]]
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[[Category: Glycoprotein]]
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[[Category: Growth factor]]
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[[Category: Ligand-receptor complex]]
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[[Category: Membrane]]
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[[Category: Neurogenesis]]
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[[Category: Neurotrophin-3]]
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[[Category: P75ntr]]
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[[Category: Secreted]]
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[[Category: Signaling protein]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:16:01 2009''
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Current revision

Crystal Structure of the Neurotrophin-3 and p75NTR Symmetrical Complex

PDB ID 3buk

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