2p0d

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{{Seed}}
 
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[[Image:2p0d.png|left|200px]]
 
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==ArhGAP9 PH domain in complex with Ins(1,4,5)P3==
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The line below this paragraph, containing "STRUCTURE_2p0d", creates the "Structure Box" on the page.
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<StructureSection load='2p0d' size='340' side='right'caption='[[2p0d]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2p0d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P0D FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.811&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>
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{{STRUCTURE_2p0d| PDB=2p0d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p0d OCA], [https://pdbe.org/2p0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p0d RCSB], [https://www.ebi.ac.uk/pdbsum/2p0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p0d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RHG09_HUMAN RHG09_HUMAN] GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix.<ref>PMID:11396949</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p0/2p0d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p0d ConSurf].
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<div style="clear:both"></div>
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===ArhGAP9 PH domain in complex with Ins(1,4,5)P3===
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==See Also==
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*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_17339315}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17339315 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17339315}}
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==About this Structure==
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2P0D is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0D OCA].
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==Reference==
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<ref group="xtra">PMID:17339315</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blasutig, I.]]
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[[Category: Large Structures]]
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[[Category: Ceccarelli, D F.J.]]
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[[Category: Blasutig I]]
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[[Category: Goudreault, M.]]
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[[Category: Ceccarelli DFJ]]
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[[Category: Pawson, T.]]
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[[Category: Goudreault M]]
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[[Category: Ruston, J.]]
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[[Category: Pawson T]]
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[[Category: Sicheri, F.]]
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[[Category: Ruston J]]
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[[Category: Pleckstrin homology domain]]
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[[Category: Sicheri F]]
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[[Category: Protein-phosphoinositide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:20:44 2009''
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Current revision

ArhGAP9 PH domain in complex with Ins(1,4,5)P3

PDB ID 2p0d

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