3b7x
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:3b7x.png|left|200px]] | ||
| - | + | ==Crystal structure of human FK506-Binding Protein 6== | |
| - | + | <StructureSection load='3b7x' size='340' side='right'caption='[[3b7x]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3b7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7X FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7x OCA], [https://pdbe.org/3b7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7x RCSB], [https://www.ebi.ac.uk/pdbsum/3b7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7x ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/FKBP6_HUMAN FKBP6_HUMAN] Note=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FKBP6_HUMAN FKBP6_HUMAN] PPIases accelerate the folding of proteins. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/3b7x_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b7x ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[FKBP 3D structures|FKBP 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
| - | [[Category: Butler-Cole | + | [[Category: Butler-Cole C]] |
| - | [[Category: Davis | + | [[Category: Davis T]] |
| - | [[Category: Dhe-Paganon | + | [[Category: Dhe-Paganon S]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Paramanathan | + | [[Category: Paramanathan R]] |
| - | + | [[Category: Walker JR]] | |
| - | [[Category: Walker | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | |
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Current revision
Crystal structure of human FK506-Binding Protein 6
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