1eyb

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{{Seed}}
 
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[[Image:1eyb.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF APO HUMAN HOMOGENTISATE DIOXYGENASE==
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The line below this paragraph, containing "STRUCTURE_1eyb", creates the "Structure Box" on the page.
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<StructureSection load='1eyb' size='340' side='right'caption='[[1eyb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1eyb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EYB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1eyb| PDB=1eyb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eyb OCA], [https://pdbe.org/1eyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eyb RCSB], [https://www.ebi.ac.uk/pdbsum/1eyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eyb ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HGD_HUMAN HGD_HUMAN] Defects in HGD are the cause of alkaptonuria (AKU) [MIM:[https://omim.org/entry/203500 203500]. AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis.<ref>PMID:8782815</ref> <ref>PMID:9154114</ref> <ref>PMID:9529363</ref> <ref>PMID:9630082</ref> <ref>PMID:10205262</ref> <ref>PMID:10340975</ref> <ref>PMID:10482952</ref> <ref>PMID:10594001</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/HGD_HUMAN HGD_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/1eyb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eyb ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF APO HUMAN HOMOGENTISATE DIOXYGENASE===
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10876237}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10876237 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_10876237}}
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==About this Structure==
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1EYB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EYB OCA].
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==Reference==
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<ref group="xtra">PMID:10876237</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Homogentisate 1,2-dioxygenase]]
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[[Category: Large Structures]]
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[[Category: Cordoba, S M.de.]]
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[[Category: Mueller HA]]
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[[Category: Mueller, H A.]]
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[[Category: Penalva MA]]
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[[Category: Penalva, M A.]]
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[[Category: Timm DE]]
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[[Category: Timm, D E.]]
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[[Category: Titus GP]]
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[[Category: Titus, G P.]]
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[[Category: De Cordoba SM]]
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[[Category: Beta sandwich]]
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[[Category: Jelly roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:31:10 2009''
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Current revision

CRYSTAL STRUCTURE OF APO HUMAN HOMOGENTISATE DIOXYGENASE

PDB ID 1eyb

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