1su9

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{{Seed}}
 
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[[Image:1su9.png|left|200px]]
 
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==Reduced structure of the soluble domain of ResA==
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The line below this paragraph, containing "STRUCTURE_1su9", creates the "Structure Box" on the page.
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<StructureSection load='1su9' size='340' side='right'caption='[[1su9]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1su9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SU9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1su9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1su9 OCA], [https://pdbe.org/1su9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1su9 RCSB], [https://www.ebi.ac.uk/pdbsum/1su9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1su9 ProSAT]</span></td></tr>
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{{STRUCTURE_1su9| PDB=1su9 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RESA_BACSU RESA_BACSU] Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis. May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached. Does not play a role in sporulation.<ref>PMID:12637552</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/su/1su9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1su9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Post-translational maturation of cytochromes c involves the covalent attachment of heme to the Cys-Xxx-Xxx-Cys-His motif of the apo-cytochrome. For this process, the two cysteines of the motif must be in the reduced state. In bacteria, this is achieved by dedicated, membrane-bound thiol-disulfide oxidoreductases with a high reducing power, which are essential components of cytochrome c maturation systems and are also linked to cellular disulfide-bond formation machineries. Here we report high-resolution structures of oxidized and reduced states of a soluble, functional domain of one such oxidoreductase, ResA, from Bacillus subtilis. The structures elucidate the structural basis of the protein's high reducing power and reveal the largest redox-coupled conformational changes observed to date in any thioredoxin-like protein. These redox-coupled changes alter the protein surface and illustrate how the redox state of ResA predetermines to which substrate it binds. Furthermore, a polar cavity, present only in the reduced state, may confer specificity to recognize apo-cytochrome c. The described features of ResA are likely to be general for bacterial cytochrome c maturation systems.
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===Reduced structure of the soluble domain of ResA===
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Structural basis of Redox-coupled protein substrate selection by the cytochrome c biosynthesis protein ResA.,Crow A, Acheson RM, Le Brun NE, Oubrie A J Biol Chem. 2004 May 28;279(22):23654-60. Epub 2004 Mar 26. PMID:15047692<ref>PMID:15047692</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1su9" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15047692}}, adds the Publication Abstract to the page
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*[[Protein disulfide oxidoreductase|Protein disulfide oxidoreductase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15047692 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15047692}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1SU9 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SU9 OCA].
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==Reference==
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<ref group="xtra">PMID:15047692</ref><references group="xtra"/>
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Acheson, R M.]]
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[[Category: Large Structures]]
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[[Category: Brun, N E.Le.]]
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[[Category: Acheson RM]]
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[[Category: Crow, A.]]
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[[Category: Crow A]]
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[[Category: Oubrie, A.]]
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[[Category: Le Brun NE]]
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[[Category: Alpha-beta protein]]
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[[Category: Oubrie A]]
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[[Category: Membrane protein]]
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[[Category: Soluble domain]]
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[[Category: Thioredoxin-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:34:37 2009''
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Current revision

Reduced structure of the soluble domain of ResA

PDB ID 1su9

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