1p51

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{{Seed}}
 
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[[Image:1p51.png|left|200px]]
 
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==Anabaena HU-DNA cocrystal structure (AHU6)==
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The line below this paragraph, containing "STRUCTURE_1p51", creates the "Structure Box" on the page.
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<StructureSection load='1p51' size='340' side='right'caption='[[1p51]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1p51]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Anabaena_sp. Anabaena sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P51 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p51 OCA], [https://pdbe.org/1p51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p51 RCSB], [https://www.ebi.ac.uk/pdbsum/1p51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p51 ProSAT]</span></td></tr>
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{{STRUCTURE_1p51| PDB=1p51 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DBH_NOSS1 DBH_NOSS1] Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. It is essential for heterocyst differentiation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/1p51_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p51 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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HU and IHF are members of a family of prokaryotic proteins that interact with the DNA minor groove in a sequence-specific (IHF) or non-specific (HU) manner to induce and/or stabilize DNA bending. HU plays architectural roles in replication initiation, transcription regulation and site-specific recombination, and is associated with bacterial nucleoids. Cocrystal structures of Anabaena HU bound to DNA (1P71, 1P78, 1P51) reveal that while underlying proline intercalation and asymmetric charge neutralization mechanisms of DNA bending are similar for IHF and HU, HU stabilizes different DNA bend angles ( approximately 105-140 degrees ). The two bend angles within a single HU complex are not coplanar, and the resulting dihedral angle is consistent with negative supercoiling. Comparison of HU-DNA and IHF-DNA structures suggests that sharper bending is correlated with longer DNA binding sites and smaller dihedral angles. An HU-induced bend may be better modeled as a hinge, not a rigid bend. The ability to induce or stabilize varying bend angles is consistent with HU's role as an architectural cofactor in many different systems that may require differing geometries.
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===Anabaena HU-DNA cocrystal structure (AHU6)===
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Flexible DNA bending in HU-DNA cocrystal structures.,Swinger KK, Lemberg KM, Zhang Y, Rice PA EMBO J. 2003 Jul 15;22(14):3749-60. PMID:12853489<ref>PMID:12853489</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12853489}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1p51" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12853489 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12853489}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Anabaena sp]]
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1P51 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Anabaena_sp. Anabaena sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P51 OCA].
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[[Category: Large Structures]]
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[[Category: Lemberg KM]]
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==Reference==
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[[Category: Rice PA]]
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<ref group="xtra">PMID:12853489</ref><references group="xtra"/>
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[[Category: Swinger KK]]
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[[Category: Anabaena sp.]]
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[[Category: Zhang Y]]
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[[Category: Lemberg, K M.]]
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[[Category: Rice, P A.]]
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[[Category: Swinger, K K.]]
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[[Category: Zhang, Y.]]
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[[Category: Dna bending]]
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[[Category: Hu]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:35:19 2009''
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Current revision

Anabaena HU-DNA cocrystal structure (AHU6)

PDB ID 1p51

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