1lv9

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{{Seed}}
 
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[[Image:1lv9.png|left|200px]]
 
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==CXCR3 Binding Chemokine IP-10/CXCL10==
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The line below this paragraph, containing "STRUCTURE_1lv9", creates the "Structure Box" on the page.
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<StructureSection load='1lv9' size='340' side='right'caption='[[1lv9]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LV9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene></td></tr>
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{{STRUCTURE_1lv9| PDB=1lv9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lv9 OCA], [https://pdbe.org/1lv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lv9 RCSB], [https://www.ebi.ac.uk/pdbsum/1lv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lv9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CXL10_HUMAN CXL10_HUMAN] Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lv/1lv9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lv9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of IP-10 was solved by NMR spectroscopy and represents the first structure from the class of agonists toward the receptor CXCR3. CXCR3 binding chemokines are unique in their ability to bind receptors from both the CC and CXC classes of chemokine receptors. An unusual structural feature of IP-10 was identified that may provide the basis for the ability of IP-10 to bind both CXCR3 and CCR3. The surface of IP-10 that interacts with the N-terminus of CXCR3 was defined by monitoring changes in the NMR spectrum of IP-10 upon addition of a CXCR3 N-terminal peptide. These studies indicated that the interaction involves a hydrophobic cleft, formed by the N-loop and 40s-loop region of IP-10, similar to the interaction surface observed for other chemokines such as IL-8. An additional region of interaction was observed that consists of a hydrophobic cleft formed by the N-terminus of IP-10 and 30s-loop of IP-10.
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===CXCR3 Binding Chemokine IP-10/CXCL10===
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The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.,Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD Biochemistry. 2002 Aug 20;41(33):10418-25. PMID:12173928<ref>PMID:12173928</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1lv9" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12173928}}, adds the Publication Abstract to the page
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*[[C-X-C motif chemokine 3D structures|C-X-C motif chemokine 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12173928 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12173928}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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1LV9 is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LV9 OCA].
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[[Category: Large Structures]]
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[[Category: Booth V]]
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==Reference==
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[[Category: Clark-Lewis I]]
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<ref group="xtra">PMID:12173928</ref><references group="xtra"/>
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[[Category: Kamphuis MB]]
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[[Category: Booth, V.]]
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[[Category: Keizer DW]]
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[[Category: Clark-Lewis, I.]]
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[[Category: Sykes BD]]
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[[Category: Kamphuis, M B.]]
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[[Category: Keizer, D W.]]
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[[Category: Sykes, B D.]]
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[[Category: Chemokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:38:56 2009''
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Current revision

CXCR3 Binding Chemokine IP-10/CXCL10

PDB ID 1lv9

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