2cas

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{{Seed}}
 
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[[Image:2cas.png|left|200px]]
 
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==THE CANINE PARVOVIRUS EMPTY CAPSID STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_2cas", creates the "Structure Box" on the page.
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<StructureSection load='2cas' size='340' side='right'caption='[[2cas]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cas]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canine_parvovirus Canine parvovirus]. The May 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Parvoviruses'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_5 10.2210/rcsb_pdb/mom_2010_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CAS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cas OCA], [https://pdbe.org/2cas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cas RCSB], [https://www.ebi.ac.uk/pdbsum/2cas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cas ProSAT]</span></td></tr>
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{{STRUCTURE_2cas| PDB=2cas | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_PAVCB CAPSD_PAVCB] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptor TFRC. This attachment induces virion internalization predominantly through clathrin-endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell. Intracytoplasmic transport involves microtubules and interaction between capsid proteins and host dynein. Exposure of nuclear localization signal probably allows nuclear import of capsids (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/2cas_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cas ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of empty canine parvovirus capsids shows that residues 37 to the carboxy-terminal residue 584 (VP2 numbering) are ordered in each of the 60 subunits. The central structural motif of each subunit is the eight-stranded antiparallel beta-barrel that has been found in many other virus structures. Five beta-hairpin turns form a beta-cylindrical structure at each icosahedral 5-fold axis. The N-terminal glycine-rich sequence can be accommodated within this cylinder without excessive steric hindrance, consistent with the electron density distribution. By far the largest conformational differences between the full and empty virus were found in the region where some ordered DNA has been observed to bind in canine parvovirus full particles. Extensive interactions among 3-fold related subunits indicate that a trimeric subunit might be a viral assembly intermediate.
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===THE CANINE PARVOVIRUS EMPTY CAPSID STRUCTURE===
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The canine parvovirus empty capsid structure.,Wu H, Rossmann MG J Mol Biol. 1993 Sep 20;233(2):231-44. PMID:8377200<ref>PMID:8377200</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2cas" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_8377200}}, adds the Publication Abstract to the page
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*[[Canine parvovirus|Canine parvovirus]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8377200 is the PubMed ID number.
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_8377200}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2CAS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Canine_parvovirus Canine parvovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CAS OCA].
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==Reference==
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<ref group="xtra">PMID:8377200</ref><references group="xtra"/>
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[[Category: Canine parvovirus]]
[[Category: Canine parvovirus]]
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[[Category: Rossmann, M.]]
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[[Category: Large Structures]]
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[[Category: Wu, H.]]
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[[Category: Parvoviruses]]
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[[Category: Icosahedral virus]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Parvovirus coat protein]]
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[[Category: Rossmann MG]]
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[[Category: Wu H]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:45:38 2009''
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Current revision

THE CANINE PARVOVIRUS EMPTY CAPSID STRUCTURE

PDB ID 2cas

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