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2z6e

From Proteopedia

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{{Seed}}
 
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[[Image:2z6e.png|left|200px]]
 
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<!--
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==Crystal Structure of Human DAAM1 FH2==
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The line below this paragraph, containing "STRUCTURE_2z6e", creates the "Structure Box" on the page.
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<StructureSection load='2z6e' size='340' side='right'caption='[[2z6e]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2z6e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z6E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6e OCA], [https://pdbe.org/2z6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z6e RCSB], [https://www.ebi.ac.uk/pdbsum/2z6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z6e ProSAT]</span></td></tr>
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{{STRUCTURE_2z6e| PDB=2z6e | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of Human DAAM1 FH2===
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[https://www.uniprot.org/uniprot/DAAM1_HUMAN DAAM1_HUMAN] Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.<ref>PMID:16630611</ref> <ref>PMID:17482208</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_17986009}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17986009 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/2z6e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17986009}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z6e ConSurf].
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2Z6E is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6E OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:17986009</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fukai, S.]]
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[[Category: Large Structures]]
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[[Category: Higashi, T.]]
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[[Category: Fukai S]]
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[[Category: Horiuchi, H.]]
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[[Category: Higashi T]]
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[[Category: Kita, T.]]
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[[Category: Horiuchi H]]
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[[Category: Nureki, O.]]
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[[Category: Kita T]]
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[[Category: Sato, Y.]]
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[[Category: Nureki O]]
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[[Category: Shirakawa, R.]]
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[[Category: Sato Y]]
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[[Category: Yamashita, M.]]
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[[Category: Shirakawa R]]
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[[Category: Alternative splicing]]
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[[Category: Yamashita M]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Protein fibril regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:48:37 2009''
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Current revision

Crystal Structure of Human DAAM1 FH2

PDB ID 2z6e

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