2h8n

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{{Seed}}
 
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[[Image:2h8n.png|left|200px]]
 
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==Structure of a glutamine-rich domain from histone deacetylase 4==
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The line below this paragraph, containing "STRUCTURE_2h8n", creates the "Structure Box" on the page.
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<StructureSection load='2h8n' size='340' side='right'caption='[[2h8n]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2h8n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H8N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h8n OCA], [https://pdbe.org/2h8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h8n RCSB], [https://www.ebi.ac.uk/pdbsum/2h8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h8n ProSAT]</span></td></tr>
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{{STRUCTURE_2h8n| PDB=2h8n | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HDAC4_HUMAN HDAC4_HUMAN] Defects in HDAC4 are the cause of brachydactyly-mental retardation syndrome (BDMR) [MIM:[https://omim.org/entry/600430 600430]. A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism.<ref>PMID:20691407</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/HDAC4_HUMAN HDAC4_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.<ref>PMID:10523670</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/2h8n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h8n ConSurf].
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<div style="clear:both"></div>
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===Structure of a glutamine-rich domain from histone deacetylase 4===
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==See Also==
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17360518 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_17360518}}
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==About this Structure==
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2H8N is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H8N OCA].
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==Reference==
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<ref group="xtra">PMID:17360518</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bates, D L.]]
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[[Category: Large Structures]]
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[[Category: Chen, L.]]
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[[Category: Bates DL]]
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[[Category: Guo, L.]]
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[[Category: Chen L]]
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[[Category: Han, A.]]
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[[Category: Guo L]]
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[[Category: Alpha helix]]
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[[Category: Han A]]
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[[Category: Polar zipper]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:49:22 2009''
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Current revision

Structure of a glutamine-rich domain from histone deacetylase 4

PDB ID 2h8n

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