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2i6a

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{{Seed}}
 
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[[Image:2i6a.png|left|200px]]
 
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<!--
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==Human Adenosine Kinase in Complex With 5'-Deoxy-5-Iodotubercidin==
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The line below this paragraph, containing "STRUCTURE_2i6a", creates the "Structure Box" on the page.
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<StructureSection load='2i6a' size='340' side='right'caption='[[2i6a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2i6a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I6A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5I5:7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>5I5</scene></td></tr>
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{{STRUCTURE_2i6a| PDB=2i6a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6a OCA], [https://pdbe.org/2i6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i6a RCSB], [https://www.ebi.ac.uk/pdbsum/2i6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i6a ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ADK_HUMAN ADK_HUMAN] Defects in ADK are the cause of hypermethioninemia due to adenosine kinase deficiency (HMAKD) [MIM:[https://omim.org/entry/614300 614300]. A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal.<ref>PMID:21963049</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ADK_HUMAN ADK_HUMAN] ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/2i6a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i6a ConSurf].
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<div style="clear:both"></div>
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===Human Adenosine Kinase in Complex With 5'-Deoxy-5-Iodotubercidin===
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==See Also==
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*[[Adenosine kinase 3D structures|Adenosine kinase 3D structures]]
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*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_17154503}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 17154503 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_17154503}}
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==About this Structure==
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2I6A is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6A OCA].
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==Reference==
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<ref group="xtra">PMID:17154503</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Muchmore, S W.]]
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[[Category: Large Structures]]
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[[Category: 5'-deoxy-5-iodotubercidin]]
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[[Category: Muchmore SW]]
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[[Category: Protein-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:59:24 2009''
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Current revision

Human Adenosine Kinase in Complex With 5'-Deoxy-5-Iodotubercidin

PDB ID 2i6a

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