1uvq

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{{Seed}}
 
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[[Image:1uvq.png|left|200px]]
 
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==Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide==
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The line below this paragraph, containing "STRUCTURE_1uvq", creates the "Structure Box" on the page.
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<StructureSection load='1uvq' size='340' side='right'caption='[[1uvq]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1uvq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UVQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1uvq| PDB=1uvq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uvq OCA], [https://pdbe.org/1uvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uvq RCSB], [https://www.ebi.ac.uk/pdbsum/1uvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uvq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/E9PMV2_HUMAN E9PMV2_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/1uvq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uvq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The MHC class II molecule DQ0602 confers strong susceptibility to narcolepsy but dominant protection against type 1 diabetes. The crystal structure of DQ0602 reveals the molecular features underlying these contrasting genetic properties. Structural comparisons to homologous DQ molecules with differential disease associations highlight a previously unrecognized interplay between the volume of the P6 pocket and the specificity of the P9 pocket, which implies that presentation of an expanded peptide repertoire is critical for dominant protection against type 1 diabetes. In narcolepsy, the volume of the P4 pocket appears central to the susceptibility, suggesting that the presentation of a specific peptide population plays a major role.
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===CRYSTAL STRUCTURE OF HLA-DQ0602 IN COMPLEX WITH A HYPOCRETIN PEPTIDE===
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Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.,Siebold C, Hansen BE, Wyer JR, Harlos K, Esnouf RE, Svejgaard A, Bell JI, Strominger JL, Jones EY, Fugger L Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1999-2004. Epub 2004 Feb 9. PMID:14769912<ref>PMID:14769912</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1uvq" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14769912}}, adds the Publication Abstract to the page
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*[[MHC 3D structures|MHC 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14769912 is the PubMed ID number.
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*[[MHC II 3D structures|MHC II 3D structures]]
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*[[Orexin and Orexin receptor|Orexin and Orexin receptor]]
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{{ABSTRACT_PUBMED_14769912}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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1UVQ is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UVQ OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:14769912</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bell, J I.]]
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[[Category: Large Structures]]
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[[Category: Esnouf, R E.]]
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[[Category: Bell JI]]
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[[Category: Fugger, L.]]
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[[Category: Esnouf RE]]
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[[Category: Hansen, B E.]]
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[[Category: Fugger L]]
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[[Category: Harlos, K.]]
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[[Category: Hansen BE]]
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[[Category: Jones, E Y.]]
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[[Category: Harlos K]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: Jones EY]]
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[[Category: Siebold, C.]]
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[[Category: Siebold C]]
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[[Category: Strominger, J L.]]
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[[Category: Strominger JL]]
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[[Category: Svejgaard, A.]]
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[[Category: Svejgaard A]]
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[[Category: Wyer, J R.]]
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[[Category: Wyer JR]]
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[[Category: Autoimmune disease]]
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[[Category: Diabetes]]
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[[Category: Immunology]]
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[[Category: Mhc class ii]]
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[[Category: Narcolepsy]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:19:19 2009''
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Current revision

Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide

PDB ID 1uvq

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