1lx7

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{{Seed}}
 
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[[Image:1lx7.png|left|200px]]
 
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==Structure of E. coli uridine phosphorylase at 2.0A==
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The line below this paragraph, containing "STRUCTURE_1lx7", creates the "Structure Box" on the page.
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<StructureSection load='1lx7' size='340' side='right'caption='[[1lx7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LX7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1lx7| PDB=1lx7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lx7 OCA], [https://pdbe.org/1lx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lx7 RCSB], [https://www.ebi.ac.uk/pdbsum/1lx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lx7 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1lx7 TOPSAN]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lx/1lx7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lx7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 2.0 A crystal structure has been determined for Escherichia coli uridine phosphorylase (UP), an essential enzyme in nucleotide biosynthesis that catalyzes the phosphorolytic cleavage of the C-N glycosidic bond of uridine to ribose-1-phosphate and uracil. The structure determination of two independent monomers in the asymmetric unit revealed the residue composition and atomic details of the apo configurations of each active site. The native hexameric UP enzyme was revealed by applying threefold crystallographic symmetry to the contents of the asymmetric unit. The 2.0 A model reveals a closer structural relationship to other nucleotide phosphorylase enzymes than was previously appreciated.
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===Structure of E. coli uridine phosphorylase at 2.0A===
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Structure of Escherichia coli uridine phosphorylase at 2.0 A.,Burling FT, Kniewel R, Buglino JA, Chadha T, Beckwith A, Lima CD Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):73-6. Epub 2002 Dec, 19. PMID:12499542<ref>PMID:12499542</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1lx7" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12499542}}, adds the Publication Abstract to the page
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*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12499542 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12499542}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1LX7 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LX7 OCA].
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[[Category: Beckwith A]]
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[[Category: Buglino JA]]
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==Reference==
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[[Category: Burley SK]]
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<ref group="xtra">PMID:12499542</ref><references group="xtra"/>
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[[Category: Burling T]]
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[[Category: Escherichia coli]]
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[[Category: Chadna T]]
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[[Category: Uridine phosphorylase]]
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[[Category: Kniewel R]]
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[[Category: Beckwith, A.]]
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[[Category: Lima CD]]
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[[Category: Buglino, J A.]]
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[[Category: Burley, S K.]]
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[[Category: Burling, T.]]
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[[Category: Chadna, T.]]
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[[Category: Kniewel, R.]]
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[[Category: Lima, C D.]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: New york structural genomix research consortium]]
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[[Category: Nucleotide metabolism]]
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[[Category: Nysgxrc]]
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[[Category: P12758]]
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[[Category: Phosphorylase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Udrpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:43:59 2009''
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Current revision

Structure of E. coli uridine phosphorylase at 2.0A

PDB ID 1lx7

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