1f5l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:10, 20 March 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1f5l.png|left|200px]]
 
-
<!--
+
==UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-AMILORIDE COMPLEX==
-
The line below this paragraph, containing "STRUCTURE_1f5l", creates the "Structure Box" on the page.
+
<StructureSection load='1f5l' size='340' side='right'caption='[[1f5l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1f5l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F5L FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMR:3,5-DIAMINO-N-(AMINOIMINOMETHYL)-6-CHLOROPYRAZINECARBOXAMIDE'>AMR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1f5l| PDB=1f5l | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f5l OCA], [https://pdbe.org/1f5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f5l RCSB], [https://www.ebi.ac.uk/pdbsum/1f5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f5l ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/1f5l_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f5l ConSurf].
 +
<div style="clear:both"></div>
-
===UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-AMILORIDE COMPLEX===
+
==See Also==
-
 
+
*[[Urokinase 3D Structures|Urokinase 3D Structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_10926521}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 10926521 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_10926521}}
+
-
 
+
-
==About this Structure==
+
-
1F5L is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5L OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:10926521</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: U-plasminogen activator]]
+
[[Category: Large Structures]]
-
[[Category: Jacob, U.]]
+
[[Category: Jacob U]]
-
[[Category: Karcher, A.]]
+
[[Category: Karcher A]]
-
[[Category: Schweinitz, A.]]
+
[[Category: Schweinitz A]]
-
[[Category: Sondermann, P.]]
+
[[Category: Sondermann P]]
-
[[Category: Sperl, S.]]
+
[[Category: Sperl S]]
-
[[Category: Sturzebecher, J.]]
+
[[Category: Sturzebecher J]]
-
[[Category: Zeslawska, E.]]
+
[[Category: Zeslawska E]]
-
[[Category: Human]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Serine protease]]
+
-
[[Category: Urokinase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 01:53:55 2009''
+

Current revision

UROKINASE PLASMINOGEN ACTIVATOR B-CHAIN-AMILORIDE COMPLEX

PDB ID 1f5l

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f5l"
Personal tools