2jgp

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{{Seed}}
 
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[[Image:2jgp.png|left|200px]]
 
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==Structure of the TycC5-6 PCP-C bidomain of the tyrocidine synthetase TycC==
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The line below this paragraph, containing "STRUCTURE_2jgp", creates the "Structure Box" on the page.
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<StructureSection load='2jgp' size='340' side='right'caption='[[2jgp]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jgp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2jgp| PDB=2jgp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgp OCA], [https://pdbe.org/2jgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jgp RCSB], [https://www.ebi.ac.uk/pdbsum/2jgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYCC_BREPA TYCC_BREPA] Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the bidomain PCP-C from modules 5 and 6 of the nonribosomal tyrocidine synthetase TycC was determined at 1.8 A resolution. The bidomain structure reveals a V-shaped condensation domain, the canyon-like active site groove of which is associated with the preceding peptidyl carrier protein (PCP) domain at its donor side. The relative arrangement of the PCP and the peptide bond-forming condensation (C) domain places the active sites approximately 50 A apart. Accordingly, this PCP-C structure represents a conformational state prior to peptide transfer from the donor-PCP to the acceptor-PCP domain, implying the existence of additional states of PCP-C domain interaction during catalysis. Additionally, PCP-C exerts a mode of cyclization activity that mimics peptide bond formation catalyzed by C domains. Based on mutational data and pK value analysis of active site residues, it is suggested that nonribosomal peptide bond formation depends on electrostatic interactions rather than on general acid/base catalysis.
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===STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC===
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Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase.,Samel SA, Schoenafinger G, Knappe TA, Marahiel MA, Essen LO Structure. 2007 Jul;15(7):781-92. PMID:17637339<ref>PMID:17637339</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2jgp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17637339 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17637339}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2JGP is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGP OCA].
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==Reference==
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<ref group="xtra">PMID:17637339</ref><references group="xtra"/>
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[[Category: Brevibacillus brevis]]
[[Category: Brevibacillus brevis]]
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[[Category: Essen, L O.]]
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[[Category: Large Structures]]
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[[Category: Knappe, T A.]]
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[[Category: Essen L-O]]
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[[Category: Marahiel, M A.]]
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[[Category: Knappe TA]]
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[[Category: Samel, S A.]]
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[[Category: Marahiel MA]]
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[[Category: Schoenafinger, G.]]
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[[Category: Samel SA]]
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[[Category: Antibiotic biosynthesis]]
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[[Category: Schoenafinger G]]
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[[Category: Antibiotic]]
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[[Category: Condensation domain]]
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[[Category: Ligase]]
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[[Category: Multifunctional enzyme]]
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[[Category: Nonribosomal peptide synthetase]]
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[[Category: Peptide bond formation]]
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[[Category: Peptidyl carrier domain]]
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[[Category: Phosphopantetheine]]
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[[Category: Tyrocidine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:12:52 2009''
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Current revision

Structure of the TycC5-6 PCP-C bidomain of the tyrocidine synthetase TycC

PDB ID 2jgp

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OCA

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