This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1r4q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:09, 17 April 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1r4q.png|left|200px]]
 
-
<!--
+
==Shiga toxin==
-
The line below this paragraph, containing "STRUCTURE_1r4q", creates the "Structure Box" on the page.
+
<StructureSection load='1r4q' size='340' side='right'caption='[[1r4q]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1r4q]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_dysenteriae Shigella dysenteriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R4Q FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r4q OCA], [https://pdbe.org/1r4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r4q RCSB], [https://www.ebi.ac.uk/pdbsum/1r4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r4q ProSAT]</span></td></tr>
-
{{STRUCTURE_1r4q| PDB=1r4q | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/STXA_SHIDY STXA_SHIDY] The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/1r4q_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r4q ConSurf].
 +
<div style="clear:both"></div>
-
===Shiga toxin===
+
==See Also==
-
 
+
*[[Shiga toxin 3D structures|Shiga toxin 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_15075327}}, adds the Publication Abstract to the page
+
[[Category: Large Structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 15075327 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_15075327}}
+
-
 
+
-
==About this Structure==
+
-
1R4Q is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Shigella_dysenteriae Shigella dysenteriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4Q OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:15075327</ref><references group="xtra"/>
+
[[Category: Shigella dysenteriae]]
[[Category: Shigella dysenteriae]]
-
[[Category: RRNA N-glycosylase]]
+
[[Category: Cherney MM]]
-
[[Category: Brien, A D.O.]]
+
[[Category: Fraser ME]]
-
[[Category: Cherney, M M.]]
+
[[Category: Fujinaga M]]
-
[[Category: Fraser, M E.]]
+
[[Category: James MNG]]
-
[[Category: Fujinaga, M.]]
+
[[Category: Melton-Celsa AR]]
-
[[Category: James, M N.G.]]
+
[[Category: O'Brien AD]]
-
[[Category: Melton-Celsa, A R.]]
+
[[Category: Twiddy EM]]
-
[[Category: Twiddy, E M.]]
+
-
[[Category: Ab5 toxin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:24:07 2009''
+

Current revision

Shiga toxin

PDB ID 1r4q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r4q"
Personal tools