1kgs

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{{Seed}}
 
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[[Image:1kgs.png|left|200px]]
 
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==Crystal Structure at 1.50 A of an OmpR/PhoB Homolog from Thermotoga maritima==
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The line below this paragraph, containing "STRUCTURE_1kgs", creates the "Structure Box" on the page.
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<StructureSection load='1kgs' size='340' side='right'caption='[[1kgs]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KGS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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{{STRUCTURE_1kgs| PDB=1kgs | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kgs OCA], [https://pdbe.org/1kgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kgs RCSB], [https://www.ebi.ac.uk/pdbsum/1kgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kgs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9WYN0_THEMA Q9WYN0_THEMA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kgs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kgs ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Two-component systems, the predominant signal transduction strategy used by prokaryotes, involve phosphorelay from a sensor histidine kinase (HK) to an intracellular response regulator protein (RR) that typically acts as a transcription regulator. RRs are modular proteins, usually composed of a conserved regulatory domain, which functions as a phosphorylation-activated switch, and an attached DNA binding effector domain. The crystal structure of a Thermotoga maritima transcription factor, DrrD, has been determined at 1.5 A resolution, providing the first structural information for a full-length member of the OmpR/PhoB subfamily of RRs. A small interdomain interface occurs between alpha 5 of the regulatory domain and an antiparallel sheet of the effector domain. The lack of an extensive interface in the unphosphorylated protein distinguishes DrrD from other structurally characterized multidomain RRs and suggests a different mode of interdomain regulation.
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===Crystal Structure at 1.50 A of an OmpR/PhoB Homolog from Thermotoga maritima===
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Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima.,Buckler DR, Zhou Y, Stock AM Structure. 2002 Feb;10(2):153-64. PMID:11839301<ref>PMID:11839301</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1kgs" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11839301}}, adds the Publication Abstract to the page
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*[[Response regulator|Response regulator]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11839301 is the PubMed ID number.
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*[[Response regulator 3D structure|Response regulator 3D structure]]
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== References ==
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{{ABSTRACT_PUBMED_11839301}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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1KGS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KGS OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:11839301</ref><references group="xtra"/>
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[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Buckler, D R.]]
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[[Category: Buckler DR]]
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[[Category: Stock, A M.]]
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[[Category: Stock AM]]
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[[Category: Zhou, Y.]]
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[[Category: Zhou Y]]
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[[Category: Alph-beta sandwich]]
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[[Category: Dna-binding protein]]
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[[Category: Helix-turn-helix]]
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[[Category: Response regulator]]
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[[Category: Winged-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:36:54 2009''
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Current revision

Crystal Structure at 1.50 A of an OmpR/PhoB Homolog from Thermotoga maritima

PDB ID 1kgs

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