2ovp

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{{Seed}}
 
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[[Image:2ovp.png|left|200px]]
 
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==Structure of the Skp1-Fbw7 complex==
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The line below this paragraph, containing "STRUCTURE_2ovp", creates the "Structure Box" on the page.
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<StructureSection load='2ovp' size='340' side='right'caption='[[2ovp]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ovp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OVP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ovp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovp OCA], [https://pdbe.org/2ovp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ovp RCSB], [https://www.ebi.ac.uk/pdbsum/2ovp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ovp ProSAT]</span></td></tr>
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{{STRUCTURE_2ovp| PDB=2ovp | SCENE= }}
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</table>
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== Function ==
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===Structure of the Skp1-Fbw7 complex===
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[https://www.uniprot.org/uniprot/SKP1_HUMAN SKP1_HUMAN] Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.<ref>PMID:16209941</ref> <ref>PMID:20181953</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17434132 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/2ovp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17434132}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ovp ConSurf].
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2OVP is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVP OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:17434132</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hao, B.]]
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[[Category: Large Structures]]
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[[Category: Harper, J W.]]
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[[Category: Hao B]]
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[[Category: Oehlmann, S.]]
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[[Category: Harper JW]]
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[[Category: Pavletich, N P.]]
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[[Category: Oehlmann S]]
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[[Category: Sowa, M E.]]
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[[Category: Pavletich NP]]
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[[Category: F-box]]
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[[Category: Sowa ME]]
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[[Category: Wd40 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:45:51 2009''
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Current revision

Structure of the Skp1-Fbw7 complex

PDB ID 2ovp

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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