3cok

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{{Seed}}
 
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[[Image:3cok.png|left|200px]]
 
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==Crystal structure of PLK4 kinase==
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The line below this paragraph, containing "STRUCTURE_3cok", creates the "Structure Box" on the page.
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<StructureSection load='3cok' size='340' side='right'caption='[[3cok]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3COK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3cok| PDB=3cok | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cok OCA], [https://pdbe.org/3cok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cok RCSB], [https://www.ebi.ac.uk/pdbsum/3cok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cok ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3cok TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLK4_HUMAN PLK4_HUMAN] Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2.<ref>PMID:16326102</ref> <ref>PMID:16244668</ref> <ref>PMID:17681131</ref> <ref>PMID:18239451</ref> <ref>PMID:19164942</ref> <ref>PMID:21725316</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/3cok_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cok ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of PLK4 kinase===
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3COK is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COK OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Polo kinase]]
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[[Category: Large Structures]]
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[[Category: Atwell, S.]]
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[[Category: Atwell S]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Houle, A.]]
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[[Category: Houle A]]
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[[Category: Leon, B.]]
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[[Category: Leon B]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
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[[Category: Pelletier LA]]
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[[Category: Pelletier, L A.]]
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[[Category: Sauder JM]]
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[[Category: Sauder, J M.]]
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[[Category: Atp-binding]]
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[[Category: New york sgx research center for structural genomic]]
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[[Category: Nucleotide-binding]]
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[[Category: Nysgxrc]]
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[[Category: Phosphoprotein]]
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[[Category: Plk4]]
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[[Category: Polo-like kinase 4]]
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[[Category: Polymorphism]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Sak]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Stk18]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:49:12 2009''
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Current revision

Crystal structure of PLK4 kinase

PDB ID 3cok

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