3ncm

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{{Seed}}
 
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[[Image:3ncm.png|left|200px]]
 
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==NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_3ncm", creates the "Structure Box" on the page.
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<StructureSection load='3ncm' size='340' side='right'caption='[[3ncm]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ncm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NCM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ncm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ncm OCA], [https://pdbe.org/3ncm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ncm RCSB], [https://www.ebi.ac.uk/pdbsum/3ncm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ncm ProSAT]</span></td></tr>
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{{STRUCTURE_3ncm| PDB=3ncm | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAM1_MOUSE NCAM1_MOUSE] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/3ncm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ncm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure in solution of the second Ig-module fragment of residues 117-208 of NCAM has been determined. Like the first Ig-module of residues 20-116, it belongs to the I set of the immunogloblin superfamily. Module 1 and module 2 interact weakly, and the binding sites of this interaction have been identified. The two-module fragment NCAM(20-208) is a stable dimer. Removal of the charged residues in these sites in NCAM(20-208) abolishes the dimerization. Modeling the dimer of NCAM(20-208) to fit the interactions of these charges produces one coherent binding site for the formation of two antiparallel strands of the first two NCAM modules. This mode of binding could be a major element in trans-cellular interactions in neural cell adhesion.
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===NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES===
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Structure and interactions of NCAM modules 1 and 2, basic elements in neural cell adhesion.,Jensen PH, Soroka V, Thomsen NK, Ralets I, Berezin V, Bock E, Poulsen FM Nat Struct Biol. 1999 May;6(5):486-93. PMID:10331878<ref>PMID:10331878</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10331878}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3ncm" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10331878 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10331878}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3NCM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCM OCA].
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==Reference==
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<ref group="xtra">PMID:10331878</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Berezin, V.]]
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[[Category: Berezin V]]
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[[Category: Bock, E.]]
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[[Category: Bock E]]
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[[Category: Jensen, P H.]]
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[[Category: Jensen PH]]
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[[Category: Poulsen, F M.]]
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[[Category: Poulsen FM]]
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[[Category: Soroka, V.]]
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[[Category: Soroka V]]
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[[Category: Thomsen, N K.]]
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[[Category: Thomsen NK]]
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[[Category: Cell adhesion]]
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[[Category: Glycoprotein]]
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[[Category: Gpi-anchor]]
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[[Category: Heparin-binding]]
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[[Category: Homophilic binding]]
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[[Category: Immunoglobulin fold]]
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[[Category: Neural adhesion molecule]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:40:41 2009''
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Current revision

NEURAL CELL ADHESION MOLECULE, MODULE 2, NMR, 20 STRUCTURES

PDB ID 3ncm

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