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1af3

From Proteopedia

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{{Seed}}
 
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[[Image:1af3.png|left|200px]]
 
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<!--
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==RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN==
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The line below this paragraph, containing "STRUCTURE_1af3", creates the "Structure Box" on the page.
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<StructureSection load='1af3' size='340' side='right'caption='[[1af3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1af3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AF3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1af3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1af3 OCA], [https://pdbe.org/1af3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1af3 RCSB], [https://www.ebi.ac.uk/pdbsum/1af3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1af3 ProSAT]</span></td></tr>
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{{STRUCTURE_1af3| PDB=1af3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2CL1_RAT B2CL1_RAT] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:8662675</ref> <ref>PMID:7828536</ref> <ref>PMID:18250306</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/1af3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1af3 ConSurf].
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<div style="clear:both"></div>
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===RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN===
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9346936}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9346936 is the PubMed ID number.
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</StructureSection>
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-->
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_9346936}}
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==About this Structure==
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1AF3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AF3 OCA].
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==Reference==
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<ref group="xtra">PMID:9346936</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Aritomi, M.]]
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[[Category: Aritomi M]]
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[[Category: Inohara, N.]]
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[[Category: Inohara N]]
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[[Category: Ishibashi, Y.]]
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[[Category: Ishibashi Y]]
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[[Category: Kunishima, N.]]
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[[Category: Kunishima N]]
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[[Category: Morikawa, K.]]
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[[Category: Morikawa K]]
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[[Category: Ohta, S.]]
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[[Category: Ohta S]]
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[[Category: Alternative splicing]]
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[[Category: Apoptosis]]
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[[Category: Bcl-xl]]
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[[Category: Mitochondrion]]
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[[Category: Regulatory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:44:22 2009''
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Current revision

RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN

PDB ID 1af3

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