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2ec8

From Proteopedia

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{{Seed}}
 
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[[Image:2ec8.png|left|200px]]
 
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<!--
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==Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit==
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The line below this paragraph, containing "STRUCTURE_2ec8", creates the "Structure Box" on the page.
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<StructureSection load='2ec8' size='340' side='right'caption='[[2ec8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EC8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ec8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec8 OCA], [https://pdbe.org/2ec8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ec8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ec8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec8 ProSAT]</span></td></tr>
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-->
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</table>
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{{STRUCTURE_2ec8| PDB=2ec8 | SCENE= }}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ec8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ec8 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit===
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==See Also==
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*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_17662946}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17662946 is the PubMed ID number.
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[[Category: Lax I]]
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-->
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[[Category: Mandiyan V]]
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{{ABSTRACT_PUBMED_17662946}}
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[[Category: Opatowsky Y]]
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[[Category: Schlessinger J]]
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==Disease==
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[[Category: Yuzawa S]]
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Known disease associated with this structure: Gastrointestinal stromal tumor, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Germ cell tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Leukemia, acute myeloid OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Mast cell leukemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Mastocytosis with associated hematologic disorder OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Piebaldism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]]
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[[Category: Zhang Z]]
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==About this Structure==
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2EC8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC8 OCA].
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==Reference==
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<ref group="xtra">PMID:17662946</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Lax, I.]]
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[[Category: Mandiyan, V.]]
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[[Category: Opatowsky, Y.]]
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[[Category: Schlessinger, J.]]
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[[Category: Yuzawa, S.]]
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[[Category: Zhang, Z.]]
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[[Category: Dimerization]]
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[[Category: Glycoprotein]]
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[[Category: Growth factor cytokine]]
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[[Category: Receptor tyrosine kinase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:06:19 2009''
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Current revision

Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit

PDB ID 2ec8

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