We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2hln

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:59, 30 August 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2hln.png|left|200px]]
 
-
<!--
+
==L-asparaginase from Erwinia carotovora in complex with glutamic acid==
-
The line below this paragraph, containing "STRUCTURE_2hln", creates the "Structure Box" on the page.
+
<StructureSection load='2hln' size='340' side='right'caption='[[2hln]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2hln]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Pectobacterium_atrosepticum Pectobacterium atrosepticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HLN FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-
{{STRUCTURE_2hln| PDB=2hln | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hln OCA], [https://pdbe.org/2hln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hln RCSB], [https://www.ebi.ac.uk/pdbsum/2hln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hln ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q7WWK9_PECAT Q7WWK9_PECAT]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/2hln_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hln ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The crystal structures of Erwinia carotovora L-asparaginase complexed with L-aspartate and L-glutamate were determined at 1.9 and 2.2 A, respectively, using the molecular-replacement method and were refined to R factors of about 21% in both cases. The positions of the ligands in the active site were located. A comparison of the new structures with the known structures of Escherichia coli L-asparaginase and Er. chrysanthemi L-asparaginase was performed. It was found that the arrangement of the ligands practically coincides in all three enzymes. The peculiarities of the quaternary structure of the enzyme, the possible role of water molecules in the enzyme action and the conformational changes during the catalyzed reaction are discussed.
-
===L-asparaginase from Erwinia carotovora in complex with glutamic acid===
+
Three-dimensional structures of L-asparaginase from Erwinia carotovora complexed with aspartate and glutamate.,Kravchenko OV, Kislitsin YA, Popov AN, Nikonov SV, Kuranova IP Acta Crystallogr D Biol Crystallogr. 2008 Mar;64(Pt 3):248-56. doi:, 10.1107/S0907444907065766. Epub 2008 Feb 20. PMID:18323619<ref>PMID:18323619</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2hln" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
2HLN is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Pectobacterium_atrosepticum Pectobacterium atrosepticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLN OCA].
+
*[[Asparaginase 3D structures|Asparaginase 3D structures]]
-
[[Category: Asparaginase]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Pectobacterium atrosepticum]]
[[Category: Pectobacterium atrosepticum]]
-
[[Category: Kislitsin, Y A.]]
+
[[Category: Kislitsin YA]]
-
[[Category: Kravchenko, O V.]]
+
[[Category: Kravchenko OV]]
-
[[Category: Kuranova, I P.]]
+
[[Category: Kuranova IP]]
-
[[Category: Nikonov, S V.]]
+
[[Category: Nikonov SV]]
-
[[Category: Popov, A N.]]
+
[[Category: Popov AN]]
-
[[Category: Erwinia carotovora]]
+
-
[[Category: L-asparaginase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 04:10:54 2009''
+

Current revision

L-asparaginase from Erwinia carotovora in complex with glutamic acid

PDB ID 2hln

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hln"
Personal tools